pferde spiegel 2024; 27(01): 26-35
DOI: 10.1055/a-2170-5192
CVE-Fortbildung

Primäre Immunschwächeerkrankungen des Pferdes mit Schwerpunkt auf der Common Variable Immunodeficiency (CVID) beim adulten Pferd

Bianca Schwarz

Bei Pferden mit chronischen oder wiederkehrenden Infektionen sollte immer auch an eine mögliche Immunschwäche gedacht werden. Diese ist oft sekundärer Natur, nur selten handelt es sich um eine primäre Immunschwächeerkrankung. Dieser Artikel gibt einen Überblick über die primären Immunschwächeerkrankungen des Pferdes mit einem Schwerpunkt auf der Common Variable Immunodeficiency (CVID).



Publication History

Article published online:
27 March 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Perryman LP. Primary immunodeficiencies of horses. Vet Clin North Am Equine Pract 2000; 16: 105-116
  • 2 Crisman MV, Scarratt WK. Immunodeficieny disorders in horses. Vet Clin North Am Equine Pract 2008; 24: 299-310
  • 3 Felippe MJB. Immunodeficiencies. In: Felippe MJB. ed. Equine Clinical Immunology. Ames (IA): Wiley Blackwell Publishing; 2016: 193-204
  • 4 Peng XP, Caballero-Oteyza A, Grimbacher B. Common variable immundeficiency. More pathways than roads to Rome. Annu Rev Pathol 2023; 18: 283-310
  • 5 Felippe MJB. Immunological testing and diagnostics in horses. Proceedings of the 16th ECEIM Congress, 2023: Lyon (France), 27.–28. Oktober 2023.
  • 6 Witonsky S. CVID in a horse with chronic peritonitis: Case review and overview of other immunodeficiencies. Equine Vet Educ 2010; 22: 400-402
  • 7 Cock G, Felippe MJB, Blair A. et al. Transient hypogammaglobulinaemia of the young in a Thoroghbred yearling. Equine Vet Educ 2023; 25: e86-e90
  • 8 Flaminio MJBF, Rush BR, Cox JH. et al. CD4+ and CD8+ T-lymphocytopenia in a filly with Pneumocystis carinii pneumonia. Aust Vet J 1998; 76: 399-402
  • 9 Tennent-Brown BS, Navas de Solis C, Foreman JH. et al. Common variable immunodeficiency in a horse with chronic peritonitis. Equine Vet Educ 2010; 22: 393-399
  • 10 Flaminio MJBF, Tallmadge RL, Salles-Gomes COM. et al. Common variable immunodeficiency in horses is characterized by B cell depletion in primary and secondary lymphoid tissues. J Clin Immunol 2009; 29: 107-116
  • 11 Pecoraro HL, Felippe MJB, Miller AD. et al. Neuroborreliosis in a horse with common variable immunodeficieny. J Vet Diagn Invest 2019; 31: 241-245
  • 12 Flaminio MJBF, LaCombe V, Kohn CW. et al. Common variable immunodeficiency in a horse. J Am Vet Med Assoc 2002; 221: 1296-1302
  • 13 Pellegrini-Masini A, Bentz AI, Johns IC. et al. Common variable immunodeficiency in three horses with presumptive bacterial meningitis. J Am Vet Med Assoc 2005; 227: 114-122
  • 14 James FM, Engiles JB, Beech J. Meningitis, cranial neuritis, and radiculoneuritis associated with Borrelia burgdorferi infection in a horse. J Am Vet Med Assoc 2010; 237: 1180-1185
  • 15 Tallmadge RL, Such KA, Miller KC. et al. Expression of essential B cell development genes in horses with common variable immunodeficiency. Mol Immunol 2012; 51: 169-176
  • 16 Tallmadge RL, Shen L, Tseng CT. et al. Bone marrow transcriptome and epigenome profiles of equine common variable immundeficiency patients unveil block of B lymphocyte differentiation. Clin Immunol 2015; 160: 261-276
  • 17 Wensley FM, Berryhill EH, Magdesian KG. Association of globulin concentration with prognosis in horses with lymphoma. Front Vet Sci 2023; 9: 1086010
  • 18 Davis EG. Immunomodulators. In: Felippe MJB. ed. Equine Clinical Immunology. Ames (IA): Wiley Blackwell Publishing; 2016: 243-250
  • 19 Picetti TS, Soveral LF, Miotto R. et al. Orally administered β-glucan improves the hemolytic activity of the complement system in horses. Vet World 2021; 14: 835-840
  • 20 Leleu C, Belloir M, Mainguet JM. et al. Immunostimulation par supplementation orale en beta-1,3/1,6 glucanes chez le cheval á lʼentrainement: essai randomise en double aveugle contre placebo. 41ème Journée de la Recherche Équine 2015. 165-168