Photoredox-Catalyzed C(sp2)–H Bond Functionalization Reactions: A Short Account

Jinling Li; Junjie Zhao; Teck-Peng Loh

doi:10.1055/a-2193-2682

Synlett, Table of Contents

Synlett 2024; 35(08): 840-850
DOI: 10.1055/a-2193-2682

account

Special Issue dedicated to Keith Fagnou

Photoredox-Catalyzed C(sp²)–H Bond Functionalization Reactions: A Short Account

Jinling Li

^aCollege of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, 450001, P. R. of China

,

Junjie Zhao

^aCollege of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, 450001, P. R. of China

,

Teck-Peng Loh ∗

^aCollege of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou, 450001, P. R. of China

^bDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore, Singapore

› Author Affiliations

Abstract

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Abstract

Photoredox catalysis has been undergoing rapid development and wide application in the chemical community during the past several years because of its advantages for reaction engineering. Since 2016, Loh et al. started their research on photoredox-catalyzed reaction transformations, including β-C(sp²)–H fluoroalkylation, alkylation, and acylation of enamides, C(sp²)–H phosphorylation of alkenes converted from alcohols, C(sp²)–H bromination, and alkylation of (hetero)arenes. These transformations introduce a broad range of structural differences on the C(sp²)–H bond of compounds with an extensive array of functional groups and showcase the appealing synthetic utilities of the approach.

1 Introduction

2 Photoredox-Catalyzed β-C(sp²)–H Functionalization of Enamides

3 Photoredox-Catalyzed C(sp²)–H Functionalization of Alkenes

4 Photoredox-Catalyzed C(sp²)–H Functionalization of (Hetero)Arenes

5 Conclusion

Key words

photoredox catalysis - enamides - (hetero)arenes - alkenes - (fluoro)alkylation - acylation - bromination - phosphorylation

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References

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