Präanalytik biochemischer Knochenumsatzparameter

Zusammenfassung

Die Präanalytik umfasst alle technischen und organisatorischen Abläufe der Gewinnung und Lagerung von Proben, wie Blut oder Urin, und deren sachgerechten Transport in ein für die gewünschte Untersuchung geeignetes Labor. Ihr Stellenwert wird besonders dadurch hervorgehoben, dass aktuell ein nicht unerheblicher Teil inkorrekter Laborwerte auf Fehler in den präanalytischen Abläufen und nicht auf Fehler im Labor zurückzuführen sind. Auch Knochenumsatzparameter, die zur Beurteilung der Dynamik des Knochenstoffwechsels und dem Monitoring metabolischer Knochenerkrankungen dienen, unterliegen, wie viele andere Parameter auch, nicht nur patientenabhängigen Faktoren, sondern auch Einflussgrößen wie beispielsweise Gabe von Medikamenten, Variabilität von Tag zu Tag, saisonaler, interindividueller oder intraindividueller Variation und einer zirkadianen Rhythmik. Die Zuverlässigkeit und Vergleichbarkeit von Laborwerten lässt sich also durch das Einhalten standardisierter präanalytischer Abläufe entscheidend beeinflussen.

Abstract

Preanalytics includes all technical and organizational processes involved in collecting and storing samples such as blood or urine and transporting them properly to a laboratory, which is suitable for the desired examination. Their importance is particularly emphasized by the fact that quite a few incorrect laboratory values can frequently be traced back to errors in the preanalytical processes and not to errors in the laboratory. Bone turnover parameters, which are used to assess the dynamics of bone metabolism and to monitor metabolic bone diseases, depend, like many other parameters, not only on patient-dependent factors, but are also influenced by different factors such like administration of medication, variation from day-to-day, seasonal/ interindividual/ intraindividual variability and a circadian rhythm. So the reliability and comparability of laboratory values can be significantly influenced by adhering to standardized preanalytic procedures.

Schlüsselwörter

Präanalytik - Probenmaterial - Knochenformationsmarker - Knochenresorptionsmarker - Stabilität von Proben

Key words

preanalytics - sample material - bone formation marker - bone resorption marker - stability of samples

Publication History

Received: 10 October 2023

Accepted: 26 October 2023

Article published online:
04 December 2023

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