Sensitivity of the Neuroendocrine Stress Axis in Metabolic
                    Diseases

Diana Cozma; Panagiota Siatra; Stefan R. Bornstein; Charlotte Steenblock

doi:10.1055/a-2201-6641

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2024; 56(01): 65-77
DOI: 10.1055/a-2201-6641

Review

Sensitivity of the Neuroendocrine Stress Axis in Metabolic Diseases

Diana Cozma

¹Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

,

Panagiota Siatra

¹Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

,

Stefan R. Bornstein

¹Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

²School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

³Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

,

Charlotte Steenblock

¹Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

› Author Affiliations

Abstract

Metabolic diseases are prevalent in modern society and have reached pandemic proportions. Metabolic diseases have systemic effects on the body and can lead to changes in the neuroendocrine stress axis, the critical regulator of the body’s stress response. These changes may be attributed to rising insulin levels and the release of adipokines and inflammatory cytokines by adipose tissue, which affect hormone production by the neuroendocrine stress axis. Chronic stress due to inflammation may exacerbate these effects. The increased sensitivity of the neuroendocrine stress axis may be responsible for the development of metabolic syndrome, providing a possible explanation for the high prevalence of severe comorbidities such as heart disease and stroke associated with metabolic disease. In this review, we address current knowledge of the neuroendocrine stress axis in response to metabolic disease and discuss its role in developing metabolic syndrome.

Key words

HPA axis - adipose tissue - obesity - metabolic diseases - obesity

Full Text

References

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