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Tierarztl Prax Ausg K Kleintiere Heimtiere 2023; 51(06): 422-429
DOI: 10.1055/a-2202-3316
Kasuistik

Zytologischer Nachweis eines hepatozytotropen T-Zell-Lymphoms bei einem 15 Jahre alten Kater

Cytologic evidence of hepatocytotropic T-cell-lymphoma in a 15-year-old male cat
Alina Finsterhölzl
1   Klinikum Veterinärmedizin, klinische Laboratoriumsdiagnostik und klinische Pathophysiologie, Justus-Liebig-Universität Gießen
,
Janina Müller
2   Institut für Veterinär-Pathologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Gießen
,
Sabine Gaum
3   Tierarztpraxis Dr. Gaum, Rödermark Urberach
,
Manfred Henrich
2   Institut für Veterinär-Pathologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Gießen
,
Natali Bauer
1   Klinikum Veterinärmedizin, klinische Laboratoriumsdiagnostik und klinische Pathophysiologie, Justus-Liebig-Universität Gießen
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Zusammenfassung

Die Kasuistik beschreibt ein seltenes Phänomen der Emperipolese-ähnlichen Invasion von lymphatischen Blasten in die Hepatozyten eines 15 Jahre alten Europäisch Kurzhaar-Katers. Der Kater wurde mit unspezifischen Symptomen (Inappetenz und Gewichtsverlust) vorgestellt. Die zytologische Untersuchung eines ultraschallgestützt entnommenen Feinnadelaspirates der Leber zeigte einige Hepatozyten mit einer Emperipolese-ähnlichen Invasion von lymphatischen Blasten. Ganz vereinzelte extrazellulär gelegene lymphatische Blasten wiesen eine Erythrophagie auf. Nach der zytologischen Diagnosestellung eines großzelligen Lymphoms wurde der Kater nach einer zweiwöchigen Monotherapie mit Prednisolon aufgrund seines schlechten Allgemeinbefindens euthanasiert. Zur Bestätigung der zytologischen Verdachtsdiagnose eines hepatozytotropen Lymphoms erfolgte eine postmortale Probenentnahme aus der Leber. Die Histopathologie konnte die zytologischen Befunde bestätigen. Immunhistochemisch waren die lymphatischen Zellen CD3 positiv, sodass die Diagnose eines bisher nur selten beschriebenen hepatozytotropen T-Zell-Lymphoms gestellt werden konnte.

Abstract

This case report describes the rare phenomenon of emperipolesis-like invasion of lymphatic blasts into the hepatocytes of a 15-year-old European Shorthair cat. The cat presented with nonspecific clinical signs (inappetence and weight loss). Cytologic examination of an ultrasound-guided fine-needle aspirate of the liver showed a subset of hepatocytes with emperipolesis-like invasion by lymphatic blasts. Few extracellularly located lymphatic blasts exhibited erythrophagia. Following the cytological diagnosis of large cell lymphoma and 2 weeks of monotherapy with prednisolone, the patient was euthanized due to his poor general condition. A post-mortem sample was obtained from the liver to confirm the suspected cytological diagnosis of hepatocytotropic lymphoma. Histopathology subsequently confirmed the cytologic findings. Immunohistochemically, the lymphatic blasts were positive for CD3 leading to a diagnosis of hepatocytotropic T-cell-lymphoma, which has rarely been described so far.

Schlüsselwörter

Zytologie - Leber - Hepatozyt - lymphatischer Blast - Emperipolese - Erythrophagie

Key words

Cytology - liver - hepatocyte - lymphatic blast - emperipolesis - erythrophagia


Publication History

Received: 31 August 2022

Accepted: 30 May 2023

Article published online:
06 December 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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