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Klin Monbl Augenheilkd 2024; 241(05): 619-625
DOI: 10.1055/a-2218-0237
Übersicht

Ocular Involvement in Graft-versus-Host Disease

Article in several languages: deutsch | English
Christoph Tappeiner 
1   Augenklinik, Pallas Kliniken, Olten, Schweiz
2   Klinik für Augenheilkunde, Universitätsklinikum Duisburg-Essen, Essen, Deutschland
3   Medizinische Fakultät, Universität Bern, Schweiz
,
Arnd Heiligenhaus
4   Uveitis Zentrum, Augenzentrum am St. Franziskus Hospital, Münster, Deutschland
5   Universität Duisburg-Essen, Essen, Deutschland
,
Tina Dietrich-Ntoukas
6   Klinik für Augenheilkunde, Charité – Universitätsmedizin Berlin, Deutschland
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Abstract

In ocular graft-versus-host disease (GVHD), an inflammatory reaction occurs at the ocular surface after transplantation of allogeneic hematopoietic stem cells. Self-reactive T cells of the donor are particularly responsible for this. This can lead to a pronounced wetting disorder of the ocular surface, conjunctival hyperemia, and corneal ulceration up to perforation. The ocular GVHD is associated with a high degree of suffering, such as pain, photophobia, and reduction in visual acuity. This review provides an overview of typical ophthalmological findings, topical and systemic therapeutic approaches, and concomitant measures (e.g., scleral lenses, punctum plugs) and the appropriate management of complications.

Key words

graft-versus-host disease (GVHD) - allogeneic hematopoietic cell transplantation (HCT) - diagnosis - classification - therapy


Publication History

Received: 06 November 2023

Accepted: 21 November 2023

Article published online:
23 January 2024

© 2024. Thieme. All rights reserved.

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