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Synthesis 2024; 56(14): 2234-2238
DOI: 10.1055/a-2235-5080
DOI: 10.1055/a-2235-5080
paper
Short Synthesis of Dopamine Agonist Rotigotine
The authors thank the Council of Scientific and Industrial Research (CSIR), C.S. thanks the University Grants Commission (UGC), and SK thanks CSIR for a research fellowship. S. C. thanks the Science and Engineering Research Board (SERB), Government of India for J C Bose fellowship (SB/S2/JCB-002/2015).
Abstract
A practical and short synthesis of FDA approved drug, Rotigotine, is achieved in two steps from 5-methoxy-2-tetralone, which in turn was synthesised by [4+2] cycloaddition of the in situ generated methoxyaryne from its precursor aryl triflate with benzyloxybutadiene or from 4-methoxyindanone via ring expansion using trimethylsilyldiazomethane.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2235-5080.
- Supporting Information
Publication History
Received: 10 November 2023
Accepted after revision: 27 December 2023
Accepted Manuscript online:
27 December 2023
Article published online:
29 January 2024
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