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Synlett
DOI: 10.1055/a-2272-8163
DOI: 10.1055/a-2272-8163
letter
Carbohydrate Chemistry in China
Fragments Synthesis of A. baumannii ATCC 17961 O-Antigen
This work was financially supported by the National Natural Science Foundation of China (22377043, 22167015, 22267010) and the Jiangxi Provincial Department of Science and Technology (jxsq2020101084, 20224ACB213006, 20212ACB213005).
Abstract
Acinetobacter baumannii can cause many diseases including septicemia, pneumonia, meningitis, soft tissue, and urinary tract infections. Herein, we described the synthesis of one trisaccharide and two tetrasaccharide fragments derived from A. baumannii ATCC 17961 O-antigen that can be used for screening novel glyco-epitopes and for developing a synthetic carbohydrate-based vaccine against A. baumannii infection. The overall yields for the synthesis of the desired trisaccharide 1, tetrasaccharide 2, and tetrasaccharide 3 are 26.8% (8 steps), 21.6% (9 steps), and 24.5% (6 steps), respectively.
Key words
Acinetobacter baumannii 17961 - oligosaccharides - synthesis - glyco-epitopes - carbohydrate-based vaccinesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2272-8163.
- Supporting Information
Publication History
Received: 28 December 2023
Accepted after revision: 20 February 2024
Accepted Manuscript online:
20 February 2024
Article published online:
04 March 2024
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