Abstract
Combinations of medications are frequently employed when their effects are
similar. Beyond aiding in the reduction of medication dosages, this approach may
yield additional positive outcomes. Studies have shown that zinc can mitigate
anxiety-related behavior in laboratory animals. This study aimed to investigate
the potential stabilizing effects of zinc chloride and diazepam in Wistar albino
rats.
Five groups, each comprising six animals. Test groups included two combinations
of zinc chloride and diazepam, each with two different doses of diazepam (1 and
2 mg/kg) and 10 mg/kg of zinc chloride. Four established anxiety models—the
Elevated Plus Maze (EPM), the hole board, the light and dark box, and the mirror
chamber—were employed to assess the anxiolytic effects. The combination of zinc
chloride and diazepam proved to be more effective than the individual doses of
zinc chloride and diazepam, indicating enhanced anxiolytic effects.
Keywords
elevated plus maze - synergism - hole board - light and dark - zinc - anxiety
