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DOI: 10.1055/a-2337-3687
Perioperative Management for Port Catheter Procedures in Pediatric Patients with Severe Hemophilia and Inhibitors
Abstract
Background The objective of this systematic study was to assess the perioperative management and outcome of surgery in pediatric patients with hemophilia A/B and inhibitors compared to nonhemophilic pediatric patients.
Methods The surgical outcome of 69 port catheter operations in patients with hemophilia who developed inhibitory antibodies against the administered factor was compared to 51 procedures in the control group. In the patients with hemophilia and inhibitors, a standardized protocol for recombinant activated factor VII was used to prevent perioperative bleeding.
Results Hemophilic pediatric patients with inhibitors showed no significant differences in perioperative management (blood transfusion: p = 0.067, duration of surgery: p = 0.69; p = 0.824) in comparison to patients without hemophilia. The length of hospital stay was significantly longer in pediatric patients with hemophilia and inhibitors (20 days vs. 4 days for insertion; 12 days vs. 1 day for explantation). Moreover, no statistically significant difference was found for secondary bleeding (three patients with hemophilia vs. none in the control group; p = 0.11) or surgical complications (five hemophilia patients vs. none with grade I complication; one hemophilia patient vs. none with grade II complications; p = 0.067).
Conclusion This study has demonstrated that port catheter insertion and removal is safe in these patients. Moreover, it shows the importance of a coordinated approach with a multidisciplinary team.
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Introduction
Hemophilia A and B are inherited bleeding disorders characterized by a deficiency of clotting factor VIII (FVIII) in hemophilia A and factor IX (FIX) in hemophilia B. Nowadays, prophylactic treatment with clotting factor concentrate is the gold standard of therapy and key to a good long-term outcome. Especially bleeding into the joint is the main cause of chronic pain and disability in these patients. Prophylactic administration of factor concentrate in children with severe hemophilia should start early in childhood before manifestation of the first joint bleed.[1] [2] [3]
However, up to a third of patients with severe hemophilia A and 3% of patients with severe hemophilia B develop inhibitory antibodies against the administered factor that leave the patient at risk for life-threatening bleeding. Inhibitor development usually occurs within the first 50 days of treatment mainly triggered by the type of the underlying mutation.[4] Immune tolerance induction (ITI) with frequent application of high doses of factor concentrate was the treatment of choice, while this study was conducted for patients with inhibitors and is successful in about 70% of patients with hemophilia A[5] and in 25% of patients with hemophilia B.[6] However, recently the humanized bispecific antibody with affinity to FIX/FIXa and FX emicizumab has expanded options to treat hemophilia A. Studies showed that emicizumab prophylaxis was highly effective at preventing bleeding in patients with and without inhibitors and therefore the need for inhibitor eradication has become less certain for patients.[7] [8] Especially in very young children, venipuncture is often difficult and traumatic. For ITI with frequent administration of coagulation factors, central venous access devices (CVADs) are necessary to guarantee clotting factor application and to avoid repeated traumatic peripheral venous punctures.[9] [10] Furthermore, a safe venous access enables parents to perform home treatment after parent training. Recent studies showed no difference in perioperative complications in adult patients with hemophilia without inhibitors undergoing surgery such as appendectomy, inguinal hernia repair, hemorrhoidectomy, cholecystectomy, and transurethral prostate or bladder surgery. Compared to controls, only the duration of hospital stay was significantly longer.[11] [12] [13]
The objective of this study was to assess the perioperative management and outcome of surgery in children with hemophilia and inhibitors compared to nonhemophilic pediatric patients.
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Materials and Methods
Study Design and Patients
This retrospective study included a total of 59 consecutive patients who underwent port catheter insertions and/or explantations at the University Hospital Bonn and the Asklepios Children's Hospital St. Augustin, Germany, between 1992 and 2017. Informed consent was obtained from all patients and the study was approved by the Medical Ethics Committee. The surgical outcome of the 69 port catheter operations for ITI in patients with hemophilia who developed inhibitory antibodies against the administered factor was compared to 51 procedures in cancer patients requiring a port catheter insertion for chemotherapy.
Data were collected regarding patient's age, gender, diagnosis and indication for insertion, type of mutation, date of insertion and removal of port catheter, complications, duration of operation, length of hospital stay, and the protocol of peri- and postoperative factor administration.
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Perioperative Clotting Factor Therapy
To prevent perioperative bleeding, the following protocol was applied. Administration of recombinant activated FVII (rFVIIa; 90–100 µg per kg body weight [BW]):
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Day of surgery: 2 hours preoperatively, at incision, then every 2 hours.
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1st and 2nd postoperative day every 2 hours.
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3rd and 4th postoperative day every 3 hours.
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5th and 6th postoperative day every 4 hours.
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7th and 8th postoperative day every 6 hours.
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9th and 10th postoperative day every 8 hours.
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11th and 12th postoperative day every 12 hours.
After completing the protocol, induction of immune tolerance was continued with high doses of FVIII concentrate twice daily 100 IE/kg BW and prothrombin complex concentrate twice daily 50 IE/kg BW.
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Surgical Approach
Pediatric surgeons implanted all the devices under general anesthesia. All patients received antibiotic prophylaxis before insertion. Two techniques were used for catheter insertion: open cut-down technique and percutaneous technique. Sites of insertion included the subclavian, internal jugular, and external jugular veins.
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Statistical Analysis
We performed statistical analysis using SPSS version 25 (IBM Corp., IBM SPSS Statistics, Chicago, Illinois, United States). The continuous variables were presented as means and standard deviation, and categorical variables were presented as numbers and percent. To determine statistical significance, the Mann–Whitney U-test was used. Categorical variables were compared using the chi-square test if the expected frequency was less than 5. A p-value of less than 0.05 was considered statistically significant.
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Results
Patient Characteristics
During the study period, a total of 69 port catheter insertion and removal procedures was performed in 34 hemophilia patients. The median age of patients was 1 year (range: 0–15 years) and the median weight was 10.9 kg (range: 7–46 kg). All patients were male. Patient characteristics are shown in [Table 1].
Hemophilia patients |
Control patients |
p-Value |
|
---|---|---|---|
Number of patients |
34 |
25 |
|
Age (median) |
1 |
12 |
|
Sex |
|||
Male |
34 |
10 |
|
Female |
0 |
15 |
|
Weight (kg) |
10.9 |
38.2 |
|
Procedures (total) |
69 |
51 |
|
First implantation |
31 |
30 |
|
First explantation |
14 |
20 |
|
Second implantation |
8 |
||
Second explantation |
8 |
||
Change |
8 |
1 |
|
Duration of surgery (min) |
|||
Implantation |
40 |
47 |
0.824 |
Explantation |
20 |
20 |
0.690 |
Hospital stay (d) |
|||
Implantation |
20 |
4 |
0.001 |
Explantation |
12 |
1 |
0.001 |
Complications[a] |
|||
Grade I |
5 |
0 |
0.067 |
Grade II |
1 |
0 |
|
Secondary bleeding[b] |
3 |
0 |
0.110 |
a Complications according to the Clavien–Dindo classification.
b Bleeding occurring within 10 days after the operation.
Twenty-four patients (70%) had developed clinically relevant inhibitors (≥0.4 Bethesda units/mL) before catheter insertion. In 18 (75%) of these patients, an Intron 22 inversion was detected in the F8 gene. Intron 22 inversion has a 25 to 30% risk for inhibitor development.[14] The average length of hospitalization was 20 days after insertion and 12 days after removal of port catheter.
In the control group (n = 25), a total of 51 port catheter insertion and removal procedures were performed during the study period. The median age of patients was 12 years (range: 0–17 years) and the median weight was 38.2 kg (10.5–101 kg). Fifteen patients were female and 10 were male.
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Duration of Surgery
The duration of surgery was defined as cut to suture time. In pediatric hemophilic patients, the mean length of operation was 40 minutes (range: 28–140 minutes) for port catheter placement and 20 minutes for its removal. In the control group, the median duration of surgery was 47 minutes (range: 28–82 minutes) for port catheter placement and 20 minutes for its removal. When comparing the two groups, no significant difference was found (p = 0.69; p = 0.824).
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Length of Hospital Stay
The length of hospital stay was significantly longer in pediatric patients with hemophilia and inhibitors (20 days for port catheter insertion and 12 days for explantation) compared to the control group (4 days in patients with port catheter placement and 1 day for its removal) ([Table 1]).
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Blood Loss and Postoperative Complications
The mean preoperative hemoglobin level in pediatric hemophilic patients was 11.2 mg/dL (range: 9–13.1) and 11.1 mg/dL (range: 8.4–12.8) in the control group. The mean postoperative hemoglobin level in pediatric hemophilic patients was 10.5 mg/dL (range: 8.4–12.9) and 11.1 (range: 9.9–12.4) in the control group. The hemoglobin levels did not differ when comparing the two groups ([Fig. 1]).


The severity of surgical complications was ranked according to the Clavien–Dindo classification.[15] Five patients developed grade I complications, such as a postoperative hematoma without the need for pharmacological treatment or surgical interventions. Postoperatively, one patient needed a blood transfusion and thus was classified as grade II complication. The control group did not develop complications ([Table 1]). There was a trend in complications in patients with hemophilia and inhibitors, but this was statistically not significant (p = 0.067).
During the port catheter placement, three patients with hemophilia developed a bleeding within 10 days after the operation (classified as secondary bleeding), while no bleeding occurred in the control group. This was statistically not significant (p = 0.11).
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Discussion
Historically, surgical procedures for patients with hemophilia were severely limited due to higher risks of intra- and postoperative bleeding, infections, and transfusion-associated transmission of infectious agents.[16] However, with the availability of purified clotting factor concentrates and improved and standardized protocols, surgery in hemophilic patients became safe.[17] With respect to Port-A-Cath implantations and explantations, there is a significant variability in real-world perioperative management. Therefore, we described our periprocedural management and its outcomes for Port-A-Cath implantations and explantations.
Recent studies for some types of abdominal and urological surgeries showed no significant differences in the length of operation, the need for blood transfusion, and the development of postoperative complications between patients with hemophilia and patients without hemophilia. In our study, the length of hospital stay was significantly longer in pediatric patients with hemophilia and inhibitors, due to further application of clotting factor concentrate for wound healing and training of the parents to use the port catheter at home to perform ITI. This was in line with recently published data.[11] [12] [18] Intensified training on port catheter handling and factor application, which is even started preoperatively, could shorten the length of hospital stay. The presence of a comprehensive home care infrastructure is also one of the key necessities to shorten the length of hospital stay. Shortening the duration of the protocol for postoperative prophylaxis to make the protocol possible for low- and middle-income bears the risk of bleeding and impaired wound healing.
Due to our periprocedural management, we also found no significant difference in the length of operation when comparing patients with and without hemophilia.
Furthermore, no statistically significant differences in postoperative complications occurred when comparing children with hemophilia to the control group, which is due to an excellent interdisciplinary work of surgeons, nurses, anesthesiologists, and hematologists. In patients with high-titer inhibitors, successful surgery has been reported under hemostatic cover with porcine FVIII, plasma-derived activated prothrombin complex concentrate (pd–aPCC), and rFVIIa. However, the published data are usually case series, mostly in adult patients.[19] [20] [21] This is a systematic study on hemophilic pediatric patients with inhibitors showing that port catheter insertion and removal is safe in this patients.
In a small case series, O'Connell et al evaluated the use of recombinant factor VIIa (rVIIa) for the treatment of acute bleeding in 12 pediatric patients and concluded that rVIIa therapy is the treatment of choice for the management of surgery and acute life- or limb-threatening bleeding.[20] rVIIa was administered at a dose of 90 μg/kg intravenously 2-hourly for the first 24 hours postoperatively and 4-hourly for the second 24 hours postoperatively and was then stopped in the absence of bleeding in one center (The National Children's Hospital, Dublin). In the other center (Great Ormond Street Hospital, London), the same dose of rVIIa was given 2-hourly for 24 hours, 3-hourly for 24 hours, and 4-hourly for 24 hours. Again, treatment was then discontinued if there was no evidence of bleeding. Our standardized protocol also administered 90 to 100 µg per kg body weight rFVIIa; however over a longer period and shorter intervals (day of surgery: 2 hours preoperatively, at incision, then every 2 hours; 1st and 2nd postoperative day every 2 hours, 3rd and 4th postoperative day every 3 hours, 5th and 6th postoperative day every 4 hours, 7th and 8th postoperative day every 6 hours, 9th and 10th postoperative day every 8 hours, 11th and 12th postoperative day every 12 hours). The more intense regimen was chosen due to clinical observations and experiences in our center. In contrast to factor VIII, bleeding control with bypassing agents is not reliably predictable. Especially in patients with high-titer inhibitors, patients may not respond well to therapy.
A systematic Cochrane review also showed high efficiency rates (>80%) for pd-aPCC in the control of acute bleeding events, with comparable tolerability and low rate of thrombotic complications.[22] Thus, this could be used as an alternative to rFVIIa.
We presented the perioperative management for port catheter insertion and explantation in pediatric patients with hemophilia and inhibitors at the Hemophilia Comprehensive Care Center Bonn. Patients with hemophilia showed no significant differences in perioperative management (blood transfusion, duration of surgery) and postoperative outcome (hemorrhages or other complications) in comparison to patients without hemophilia.
In trend, there were more bleeding complications in patients with hemophilia: five patients developed grade I complications according to the Clavien–Dindo classification, while one patient needed a blood transfusion and was classified as grade II. Nevertheless, this was statistically not significant (p = 0.067).
Ingerslev et al included two pediatric patients in a cohort of patients undergoing major surgery (synovectomy and craniotomy) where rVIIa was successfully used without complications.[23] O'Connell et al described rVIIa to be successful in resolving bleeding in a small series of children, although fibrin glue was needed in one case and red cell transfusion was necessary on two occasions.[20] The reliability and safety of rVIIa in securing perioperative hemostasis was also demonstrated by Shapiro et al.[24] In this randomized trial, two doses of FVIIa (35 vs. 90 μg/kg) were tested for a variety of procedures (including orthopedic procedures, CVAD insertion, and renal biopsies). All high-dose patients (90 μg/kg) and 12/15 low-dose patients (35 μg/kg) had satisfactory hemostasis during the first 48 hours, thus the 35 μg/kg dose was considered sub-optimal for postoperative management.
This study has several limitations, including its retrospective design and the single-center experience in the era prior to the availability of emicizumab. Therefore, the regimen and the results cannot be transferred to patients who are currently treated with emicizumab. The phase IIIb multicenter, single-arm STASEY study evaluated the safety and tolerability of emicizumab prophylaxis in people with hemophilia A aged ≥12 years with FVIII inhibitors.[25] The data support that emicizumab prophylaxis can provide hemostatic coverage during minor and major surgeries, with appropriate concomitant prophylactic hemostatic medication when required, which is in accordance with other studies.[25] [26] However, guidelines for management of surgeries in patients with hemophilia A with/without FVIII inhibitors receiving emicizumab are still missing.
Another weakness of this study is the control group, which consists of older pediatric cancer patients compared to our patients with hemophilia. Cancer can cause a prothrombotic or hypercoagulable state through an altered balance between the coagulation and fibrinolytic factors. Pediatric patients with cancer hold an increased risk of venous thromboembolism that is further increased by insertion of central venous catheters. This also might explain the differences in bleeding complications in patients with hemophilia and in patients with cancer in our study.
In conclusion, or study has demonstrated that port catheter insertion and removal is safe in pediatric patients with hemophilia that developed inhibitors. Moreover, it shows the importance of a coordinated approach with a multidisciplinary team of hematologists and surgeons.
What Is Known about This Topic?
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In patients with high-titer inhibitors, successful surgery has been reported under hemostatic cover with porcine FVIII, plasma-derived activated prothrombin complex concentrate (pd–aPCC), and recombinant activated FVII (rFVIIa). However, the published data are usually case series, mostly in adult patients.
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For Port-A-Cath implantations and explantations, there is a significant variability in real-world perioperative management.
What Does This Paper Add?
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This is a systematic study on hemophilic pediatric patients with inhibitors showing that port catheter insertion and removal is safe in these patients: no significant differences were found in perioperative management (blood transfusion, duration of surgery) and postoperative outcome (hemorrhages or other complications) in comparison to patients without hemophilia.
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A standardized protocol for surgical procedures in hemophilic pediatric patients with inhibitors.
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Conflict of Interest
The authors declare that they have no conflict of interest.
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References
- 1 Richards M, Williams M, Chalmers E. et al; Paediatric Working Party of the United Kingdom Haemophilia Doctors' Organisation. A United Kingdom Haemophilia Centre Doctors' Organization guideline approved by the British Committee for Standards in Haematology: guideline on the use of prophylactic factor VIII concentrate in children and adults with severe haemophilia A. Br J Haematol 2010; 149 (04) 498-507
- 2 Meunier S, Trossaërt M, Berger C. et al; Groupe Prophylaxie CoMETH. French guidelines. Long-term prophylaxis for severe haemophilia A and B children to prevent haemophiliac arthropathy [in French]. Arch Pediatr 2009; 16 (12) 1571-1578
- 3 Oldenburg J. Optimal treatment strategies for hemophilia: achievements and limitations of current prophylactic regimens. Blood 2015; 125 (13) 2038-2044
- 4 Saint-Remy JM, Lacroix-Desmazes S, Oldenburg J. Inhibitors in haemophilia: pathophysiology. Haemophilia 2004; 10 (Suppl. 04) 146-151
- 5 Baghaipour MR, Steen Carlsson K. Strategies for inhibitor treatment and costs in the short and long term: a critical evaluation of recent clinical studies. Eur J Haematol 2015; 94 (Suppl. 77) 30-37
- 6 Batorova A, Morongova A, Tagariello G, Jankovicova D, Prigancova T, Horakova J. Challenges in the management of hemophilia B with inhibitor. Semin Thromb Hemost 2013; 39 (07) 767-771
- 7 Oldenburg J, Mahlangu JN, Kim B. et al. Emicizumab prophylaxis in hemophilia A with inhibitors. N Engl J Med 2017; 377 (09) 809-818
- 8 Pipe SW, Shima M, Lehle M. et al. Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study. Lancet Haematol 2019; 6 (06) e295-e305
- 9 Ewenstein BM, Valentino LA, Journeycake JM. et al. Consensus recommendations for use of central venous access devices in haemophilia. Haemophilia 2004; 10 (05) 629-648
- 10 Valentino LA, Kapoor M. Central venous access devices in patients with hemophilia. Expert Rev Med Devices 2005; 2 (06) 699-711
- 11 Goldmann G, Holoborodska Y, Oldenburg J. et al. Perioperative management and outcome of general and abdominal surgery in hemophiliacs. Am J Surg 2010; 199 (05) 702-707
- 12 Lingohr P, Bensoukehal S, Matthaei H. et al. Value and risk of laparoscopic surgery in hemophiliacs-experiences from a tertiary referral center for hemorrhagic diatheses. Langenbecks Arch Surg 2014; 399 (05) 609-618
- 13 Rogenhofer S, Hauser S, Breuer A. et al. Urological surgery in patients with hemorrhagic bleeding disorders Hemophilia A, Hemophilia B, von Willebrand disease: a retrospective study with matched pairs analysis. World J Urol 2013; 31 (03) 703-707
- 14 Jenkins PV, Collins PW, Goldman E. et al. Analysis of intron 22 inversions of the factor VIII gene in severe hemophilia A: implications for genetic counseling. Blood 1994; 84 (07) 2197-2201
- 15 Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004; 240 (02) 205-213
- 16 Ingerslev J, Hvid I. Surgery in hemophilia. The general view: patient selection, timing, and preoperative assessment. Semin Hematol 2006; 43 (1, Suppl 1): S23-S26
- 17 Chapin J, Bamme J, Hsu F, Christos P, DeSancho M. Outcomes in patients with hemophilia and von Willebrand disease undergoing invasive or surgical procedures. Clin Appl Thromb Hemost 2017; 23 (02) 148-154
- 18 Ljung RC, Knobe K. How to manage invasive procedures in children with haemophilia. Br J Haematol 2012; 157 (05) 519-528
- 19 Quintana-Molina M, Martínez-Bahamonde F, González-García E. et al. Surgery in haemophilic patients with inhibitor: 20 years of experience. Haemophilia 2004; 10 (Suppl. 02) 30-40
- 20 O'Connell N, Mc Mahon C, Smith J. et al. Recombinant factor VIIa in the management of surgery and acute bleeding episodes in children with haemophilia and high responding inhibitors. Br J Haematol 2002; 116 (03) 632-635
- 21 Goudemand J, Tagariello G, Lopaciuk F. Cases of surgery in high-responder haemophilia patients. Haemophilia 2004; 10 (Suppl. 02) 46-49
- 22 Matino D, Makris M, Dwan K, D'Amico R, Iorio A. Recombinant factor VIIa concentrate versus plasma-derived concentrates for treating acute bleeding episodes in people with haemophilia and inhibitors. Cochrane Database Syst Rev 2015; 2015 (12) CD004449
- 23 Ingerslev J, Christiansen K, Calatzis A, Holm M, Sabroe Ebbesen L. Management and monitoring of recombinant activated factor VII. Blood Coagul Fibrinolysis 2000; 11 (Suppl. 01) S25-S30
- 24 Shapiro AD, Gilchrist GS, Hoots WK, Cooper HA, Gastineau DA. Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery. Thromb Haemost 1998; 80 (05) 773-778
- 25 Castaman G, Peyvandi F, Kremer Hovinga JA. et al. Surgical experience from the STASEY study of emicizumab prophylaxis in people with hemophilia A with factor VIII inhibitors. TH Open 2024; 8 (01) e42-e54
- 26 Jiménez-Yuste V, Rodríguez-Merchán EC, Matsushita T, Holme PA. Concomitant use of bypassing agents with emicizumab for people with haemophilia A and inhibitors undergoing surgery. Haemophilia 2021; 27 (04) 519-530
Address for correspondence
Publication History
Received: 22 January 2024
Accepted: 26 May 2024
Article published online:
12 September 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Richards M, Williams M, Chalmers E. et al; Paediatric Working Party of the United Kingdom Haemophilia Doctors' Organisation. A United Kingdom Haemophilia Centre Doctors' Organization guideline approved by the British Committee for Standards in Haematology: guideline on the use of prophylactic factor VIII concentrate in children and adults with severe haemophilia A. Br J Haematol 2010; 149 (04) 498-507
- 2 Meunier S, Trossaërt M, Berger C. et al; Groupe Prophylaxie CoMETH. French guidelines. Long-term prophylaxis for severe haemophilia A and B children to prevent haemophiliac arthropathy [in French]. Arch Pediatr 2009; 16 (12) 1571-1578
- 3 Oldenburg J. Optimal treatment strategies for hemophilia: achievements and limitations of current prophylactic regimens. Blood 2015; 125 (13) 2038-2044
- 4 Saint-Remy JM, Lacroix-Desmazes S, Oldenburg J. Inhibitors in haemophilia: pathophysiology. Haemophilia 2004; 10 (Suppl. 04) 146-151
- 5 Baghaipour MR, Steen Carlsson K. Strategies for inhibitor treatment and costs in the short and long term: a critical evaluation of recent clinical studies. Eur J Haematol 2015; 94 (Suppl. 77) 30-37
- 6 Batorova A, Morongova A, Tagariello G, Jankovicova D, Prigancova T, Horakova J. Challenges in the management of hemophilia B with inhibitor. Semin Thromb Hemost 2013; 39 (07) 767-771
- 7 Oldenburg J, Mahlangu JN, Kim B. et al. Emicizumab prophylaxis in hemophilia A with inhibitors. N Engl J Med 2017; 377 (09) 809-818
- 8 Pipe SW, Shima M, Lehle M. et al. Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study. Lancet Haematol 2019; 6 (06) e295-e305
- 9 Ewenstein BM, Valentino LA, Journeycake JM. et al. Consensus recommendations for use of central venous access devices in haemophilia. Haemophilia 2004; 10 (05) 629-648
- 10 Valentino LA, Kapoor M. Central venous access devices in patients with hemophilia. Expert Rev Med Devices 2005; 2 (06) 699-711
- 11 Goldmann G, Holoborodska Y, Oldenburg J. et al. Perioperative management and outcome of general and abdominal surgery in hemophiliacs. Am J Surg 2010; 199 (05) 702-707
- 12 Lingohr P, Bensoukehal S, Matthaei H. et al. Value and risk of laparoscopic surgery in hemophiliacs-experiences from a tertiary referral center for hemorrhagic diatheses. Langenbecks Arch Surg 2014; 399 (05) 609-618
- 13 Rogenhofer S, Hauser S, Breuer A. et al. Urological surgery in patients with hemorrhagic bleeding disorders Hemophilia A, Hemophilia B, von Willebrand disease: a retrospective study with matched pairs analysis. World J Urol 2013; 31 (03) 703-707
- 14 Jenkins PV, Collins PW, Goldman E. et al. Analysis of intron 22 inversions of the factor VIII gene in severe hemophilia A: implications for genetic counseling. Blood 1994; 84 (07) 2197-2201
- 15 Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004; 240 (02) 205-213
- 16 Ingerslev J, Hvid I. Surgery in hemophilia. The general view: patient selection, timing, and preoperative assessment. Semin Hematol 2006; 43 (1, Suppl 1): S23-S26
- 17 Chapin J, Bamme J, Hsu F, Christos P, DeSancho M. Outcomes in patients with hemophilia and von Willebrand disease undergoing invasive or surgical procedures. Clin Appl Thromb Hemost 2017; 23 (02) 148-154
- 18 Ljung RC, Knobe K. How to manage invasive procedures in children with haemophilia. Br J Haematol 2012; 157 (05) 519-528
- 19 Quintana-Molina M, Martínez-Bahamonde F, González-García E. et al. Surgery in haemophilic patients with inhibitor: 20 years of experience. Haemophilia 2004; 10 (Suppl. 02) 30-40
- 20 O'Connell N, Mc Mahon C, Smith J. et al. Recombinant factor VIIa in the management of surgery and acute bleeding episodes in children with haemophilia and high responding inhibitors. Br J Haematol 2002; 116 (03) 632-635
- 21 Goudemand J, Tagariello G, Lopaciuk F. Cases of surgery in high-responder haemophilia patients. Haemophilia 2004; 10 (Suppl. 02) 46-49
- 22 Matino D, Makris M, Dwan K, D'Amico R, Iorio A. Recombinant factor VIIa concentrate versus plasma-derived concentrates for treating acute bleeding episodes in people with haemophilia and inhibitors. Cochrane Database Syst Rev 2015; 2015 (12) CD004449
- 23 Ingerslev J, Christiansen K, Calatzis A, Holm M, Sabroe Ebbesen L. Management and monitoring of recombinant activated factor VII. Blood Coagul Fibrinolysis 2000; 11 (Suppl. 01) S25-S30
- 24 Shapiro AD, Gilchrist GS, Hoots WK, Cooper HA, Gastineau DA. Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery. Thromb Haemost 1998; 80 (05) 773-778
- 25 Castaman G, Peyvandi F, Kremer Hovinga JA. et al. Surgical experience from the STASEY study of emicizumab prophylaxis in people with hemophilia A with factor VIII inhibitors. TH Open 2024; 8 (01) e42-e54
- 26 Jiménez-Yuste V, Rodríguez-Merchán EC, Matsushita T, Holme PA. Concomitant use of bypassing agents with emicizumab for people with haemophilia A and inhibitors undergoing surgery. Haemophilia 2021; 27 (04) 519-530

