Exp Clin Endocrinol Diabetes 2024; 132(11): 642-649
DOI: 10.1055/a-2384-6275
Mini-Review

Diabetes Mellitus and its Association with Work Patterns and Characteristics: A Narrative Review

Anna Eleftheriou
1   Second Department of Surgery General Hospital of Nikaia and Piraeus “Agios Panteleimon”, Piraeus, Greece
,
Aikaterini Rokou
2   Laboratory of Social Medicine, Democritus University of Thrace – Alexandropoulis Campus, Alexandroupolis, Greece (Ringgold ID: RIN112220)
,
Evangelia Nena
2   Laboratory of Social Medicine, Democritus University of Thrace – Alexandropoulis Campus, Alexandroupolis, Greece (Ringgold ID: RIN112220)
,
3   Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece
› Author Affiliations

Abstract

Diabetes mellitus is a leading cause of disability with adverse effects on the quality of life. It also affects occupational health by impacting several work-related parameters. This review discusses the relationship between diabetes and absenteeism, presenteeism, work impairment and unemployment. The association between work and diabetic complications such as neuropathic pain, diabetic foot, psychological issues and hypoglycemia due to treatment is also examined. Evidence points to a relationship between diabetes and absenteeism, reduced work productivity, and, thus, overall work impairment. A stronger negative impact on work performance is mediated by painful diabetic neuropathy and diabetic foot. In addition, psychological distress has been positively correlated with total workdays lost and frequency of absence. Depression in the diabetic population has also been linked with increased absenteeism, presenteeism, and work disability. Moreover, hypoglycaemia induced by antidiabetic medication may affect work attendance and performance. Finally, diabetes has been associated with inequality in the work environment, lower job satisfaction and higher unemployment rates, mainly because of its complications.



Publication History

Received: 01 March 2024
Received: 12 August 2024

Accepted after revision: 12 August 2024

Accepted Manuscript online:
12 August 2024

Article published online:
18 September 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 International Diabetes Federation. Facts & figures. Accessed 28th February 2024 https://www.idf.org/aboutdiabetes/what-is-diabetes/facts-figures.html
  • 2 Emerging Risk Factors Collaboration. Sarwar N, Gao P. et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies. Lancet 2010; 375: 2215-2222
  • 3 Oluchi SE, Manaf RA, Ismail S. et al. Health related quality of life measurements for diabetes: A systematic review. Int J Environ Res Public Health 2021; 18: 9245
  • 4 Schur L, Han K, Kim A. et al. Disability at work: A look back and forward. J Occup Rehabil 2017; 27: 482-497
  • 5 Belita A, Mbindyo P, English M. Absenteeism amongst health workers--developing a typology to support empiric work in low-income countries and characterizing reported associations. Hum Resour Health 2013; 11: 34
  • 6 Luz J, Green MS. Sickness absenteeism from work--a critical review of the literature. Public Health Rev 1997; 25: 89-122
  • 7 Donovan TL, Moore KM, VanDen Kerkhof EG. Employee absenteeism based on occupational health visits in an urban tertiary care Canadian hospital. Public Health Nurs 2008; 25: 565-575
  • 8 Waclawski ER. Sickness absence among insulin-treated diabetic employees. Diabet Med 1990; 7: 41-44
  • 9 Skerjanc A. Sickness absence in diabetic employees. Occup Environ Med 2001; 58: 432-436
  • 10 Vijan S, Hayward RA, Langa KM. The impact of diabetes on workforce participation: Results from a national household sample. Health Serv Res 2004; 39: 1653-1669
  • 11 Tunceli K, Bradley CJ, Nerenz D. et al. The impact of diabetes on employment and work productivity. Diabetes Care 2005; 28: 2662-2667
  • 12 Robinson N. Disability and diabetes. Int Disabil Stud 1990; 12: 28-31
  • 13 De Backer G, Leynen F, De Bacquer D. et al. Diabetes mellitus in middle-aged people is associated with increased sick leave: The BELSTRESS study. Int J Occup Environ Health 2006; 12: 28-34
  • 14 Dray-Spira R, Herquelot E, Bonenfant S. et al. Impact of diabetes mellitus onset on sickness absence from work--a 15-year follow-up of the GAZEL Occupational Cohort Study. Diabet Med 2013; 30: 549-556
  • 15 Brook RA, Kleinman NL, Patel S. et al. United States comparative costs and absenteeism of diabetic ophthalmic conditions. Postgrad Med 2015; 127: 455-462
  • 16 Persson S, Johansen P, Andersson E. et al. Days absent from work as a result of complications associated with type 2 diabetes: Evidence from 20 years of linked national registry data in Sweden. Diabetes Obes Metab 2020; 22: 1586-1597
  • 17 Nexø MA, Pedersen J, Cleal B. et al. Working life expectancies among individuals with type 1 and type 2 diabetes over a 30-year period. Scand J Work Environ Health 2021; 47: 540-549
  • 18 Li AK, Nowrouzi-Kia B. Impact of diabetes mellitus on occupational health outcomes in Canada. Int J Occup Environ Med 2017; 8: 96-08
  • 19 Gutefeldt K, Hedman CA, Thyberg ISM. et al. Low health-related quality of life is strongly linked to upper extremity impairments in type 1 diabetes with a long duration. Disabil Rehabil 2021; 43: 2578-2584
  • 20 Kivimäki M, Vahtera J, Pentti J. et al. Increased sickness absence in diabetic employees: What is the role of co-morbid conditions?. Diabet Med 2007; 24: 1043-1048
  • 21 Cawley J, Rizzo JA, Haas K. The association of diabetes with job absenteeism costs among obese and morbidly obese workers. J Occup Environ Med 2008; 50: 527-534
  • 22 Testa MA, Simonson DC. Health economic benefits and quality of life during improved glycaemic control in patients with type 2 diabetes mellitus: A randomized, controlled, double-blind trial. JAMA 1998; 280: 1490-1496
  • 23 DiBonaventura M, Link C, Pollack MF. et al. The relationship between patient-reported tolerability issues with oral antidiabetic agents and work productivity among patients having type 2 diabetes. J Occup Environ Med 2011; 53: 204-210
  • 24 Kinman G. Sickness presenteeism at work: prevalence, costs and management. Br Med Bull 2019; 129: 69-78
  • 25 Mori T, Nagata T, Nagata M. et al. The impact of diabetes status on presenteeism in Japan. J Occup Environ Med 2020; 62: 654-661
  • 26 Zaghloul H, Omar O, Pallayova M. et al. Factors associated with presenteeism at work in type 2 diabetes mellitus. J Occup Environ Med 2018; 60: 1116-1119
  • 27 Hutting N, Engels JA, Heerkens YF. et al. Development and measurement properties of the Dutch version of the Stanford Presenteeism Scale (SPS-6). J Occup Rehabil 2014; 24: 268-277
  • 28 Tabano DC, Anderson ML, Ritzwoller DP. et al. Estimating the impact of diabetes mellitus on worker productivity using self-report, electronic health record and human resource data. J Occup Environ Med 2018; 60: e569-e574
  • 29 Xu Y, Tong GYY, Lee JY. Investigation on the association between diabetes distress and productivity among patients with uncontrolled type 2 diabetes mellitus in the primary healthcare institutions. Prim Care Diabetes 2020; 14: 538-544
  • 30 Araki A, Umegaki H, Sakurai T. et al. Determinants and impact of physical impairment in patient-reported outcomes among older patients with type 2 diabetes mellitus in Japan. Curr Med Res Opin 2021; 37: 393-402
  • 31 R. Associates, WPAI Scoring, 2019. Last accessed 28th February 2024 http://www.reillyassociates.net/WPAIScoring.html
  • 32 Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 1993; 4: 353-365
  • 33 Krstović-Spremo V, Račić M, Joksimović BN. et al. The effects of diabetes mellitus and hypertension on work productivity. Acta Med Acad 2014; 43: 122-133
  • 34 Yassin AS, Beckles GL, Messonnier ML. Disability and its economic impact among adults with diabetes. J Occup Environ Med 2002; 44: 136-142
  • 35 Lavigne JE, Phelps CE, Mushlin A. et al. Reductions in individual work productivity associated with type 2 diabetes mellitus. Pharmacoeconomics 2003; 21: 1123-1134
  • 36 Songer TJ, LaPorte RE, Dorman JS. et al. Employment spectrum of IDDM. Diabetes Care 1989; 12: 615-622
  • 37 Hakkarainen P, Moilanen L, Hänninen V. et al. Work ability among Finnish workers with type 1 diabetes. Occup Med (Lond) 2016; 66: 446-453
  • 38 Gore M, Brandenburg NA, Hoffman DL. et al. Burden of illness in painful diabetic peripheral neuropathy: The patients' perspectives. J Pain 2006; 7: 892-900
  • 39 Stewart WF, Ricci JA, Chee E. et al. Lost productive time and costs due to diabetes and diabetic neuropathic pain in the US workforce. J Occup Environ Med 2007; 49: 672-679
  • 40 daCosta DiBonaventura M, Cappelleri JC, Joshi AV. A longitudinal assessment of painful diabetic peripheral neuropathy on health status, productivity, and health care utilization and cost. Pain Med 2011; 12: 118-126
  • 41 Eichholz M, Alexander AH, Cappelleri JC. et al. Perspectives on the impact of painful diabetic peripheral neuropathy in a multicultural population. Clin Diabetes Endocrinol 2017; 3: 12
  • 42 Brod M. Quality of life issues in patients with diabetes and lower extremity ulcers: Patients and care givers. Qual Life Res 1998; 7: 365-372
  • 43 Cabeceira HDS, Souza DMST, Juliano Y. et al. Work ability and productivity in patients with diabetic foot. Clinics (Sao Paulo) 2019; 74: e421
  • 44 Ervasti J, Kivimäki M, Dray-Spira R. et al. Psychosocial factors associated with work disability in men and women with diabetes: A pooled analysis of three occupational cohort studies. Diabet Med 2016; 33: 208-217
  • 45 McCarthy M, Yan J, Dickson VV. Factors associated with work ability in adults with diabetes. Appl Nurs Res 2021; 61: 151478
  • 46 Ludman EJ, Katon W, Russo J. et al. Depression and diabetes symptom burden. Gen Hosp Psychiatry 2004; 26: 430-436
  • 47 Moulton CD, Murray L, Winkley K. et al. Depression and change in occupational functioning in type 2 diabetes. Occup Med (Lond) 2019; 69: 322-328
  • 48 Von Korff M, Katon W, Lin EH. et al. Work disability among individuals with diabetes. Diabetes Care 2005; 28: 1326-1332
  • 49 O'Reilly DJ, Burke N, Tarride JE. et al. Direct health-care costs and productivity costs associated with hypoglycemia in adults with type 1 and type 2 diabetes mellitus that participated in the Canadian hypoglycemia assessment tool program. Can J Diabetes 2018; 42: 659-663
  • 50 Lopez JM, Annunziata K, Bailey RA. et al. Impact of hypoglycemia on patients with type 2 diabetes mellitus and their quality of life, work productivity, and medication adherence. Patient Prefer Adherence 2014; 8: 683-692
  • 51 Pawaskar M, Iglay K, Witt EA. et al. Impact of the severity of hypoglycemia on health – Related quality of life, productivity, resource use, and costs among US patients with type 2 diabetes. J Diabetes Complications 2018; 32: 451-457
  • 52 Brod M, Christensen T, Thomsen TL. et al. The impact of non-severe hypoglycemic events on work productivity and diabetes management. Value Health 2011; 14: 665-671
  • 53 Geelhoed-Duijvestijn PH, Pedersen-Bjergaard U, Weitgasser R. et al. Effects of patient-reported non-severe hypoglycemia on healthcare resource use, work-time loss, and wellbeing in insulin-treated patients with diabetes in seven European countries. J Med Econ 2013; 16: 1453-1461
  • 54 Brod M, Wolden M, Groleau D. et al. Understanding the economic, daily functioning, and diabetes management burden of non-severe nocturnal hypoglycemic events in Canada: Differences between type 1 and type 2. J Med Econ 2014; 17: 11-20
  • 55 Fulcher G, Singer J, Castañeda R. et al. The psychosocial and financial impact of non-severe hypoglycemic events on people with diabetes: Two international surveys. J Med Econ 2014; 17: 751-761
  • 56 Pawaskar M, Witt EA, Engel SS. et al. Severity of hypoglycaemia and health-related quality of life, work productivity and healthcare costs in patients with type 2 diabetes in Europe. Endocrinol Diabetes Metab 2018; 1: e00011
  • 57 Francois R, Asenjo-Ramis S, Kammerman R. et al. Analysis of social-professional outocome of insulin-dependent diabetic patients. Pediat Inter 1984; 26: 428-432
  • 58 Mori K, Mori T, Nagata T. et al. Factors of occurrence and improvement methods of presenteeism attributed to diabetes: A systematic review. J Occup Health 2019; 61: 36-53
  • 59 Tan SY, Mei Wong JL, Sim YJ. et al. Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention. Diabetes Metab Syndr 2019; 13: 364-372
  • 60 Forouhi NG, Misra A, Mohan V. et al. Dietary and nutritional approaches for prevention and management of type 2 diabetes. BMJ 2018; 361: k2234
  • 61 Loeppke R, Haufle V, Jinnett K. et al. Medication adherence, comorbidities, and health risk impacts on workforce absence and job performance. J Occup Environ Med 2011; 53: 595-604
  • 62 Carls GS, Roebuck MC, Brennan TA. et al. Impact of medication adherence on absenteeism and short-term disability for five chronic diseases. J Occup Environ Med 2012; 54: 792-805
  • 63 Aggarwal A, Pathak S, Goyal R. Clinical and economic outcomes of continuous glucose monitoring system (CGMS) in patients with diabetes mellitus: A systematic literature review. Diabetes Res Clin Pract 2022; 186: 109825
  • 64 Charleer S, De Block C, Van Huffel L. et al. Quality of Life and Glucose Control After 1 year of nationwide reimbursement of intermittently scanned continuous glucose monitoring in adults living with type 1 diabetes (FUTURE): A prospective observational real-world cohort study. Diabetes Care 2020; 43: 389-397
  • 65 Olesen K, Cleal B, Skinner T. et al. Characteristics associated with non-disclosure of Type 2 diabetes at work. Diabet Med 2017; 34: 1116-1119