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Horm Metab Res 2024; 56(11): 761-769
DOI: 10.1055/a-2411-9344
Review

Effects of Growth Hormone on Osteoarthritis Development

Lin Sun
1   Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Xiaokun Gang
1   Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Fei Li
1   Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Weiying Guo
1   Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Mengzhao Cui
1   Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Guixia Wang
1   Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
› Author Affiliations Funding Information Youth Development Fund of the First Hospital of Jilin University | 04039890001 | National Natural Science Foundation of China | 82100871
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Abstract

Osteoarthritis (OA), a chronic joint disease characterized by primary or secondary degeneration of articular cartilage and bone dysplasia, is associated with various risk factors and is the leading cause of musculoskeletal pain and disability, severely impacting the quality of life. Growth hormone (GH), secreted by the anterior pituitary gland, is essential in mediating the growth and development of bone and cartilage. Reportedly, osteoarthritis increases, and the growth hormone decreases with age. A negative correlation between GH and OA suggests that GH may be related to the occurrence and development of OA. Considering that abnormal growth hormone levels can lead to many diseases related to bone growth, we focus on the relationship between GH and OA. In this review, we will explain the effects of GH on the growth and deficiency of bone and cartilage based on the local pathological changes of osteoarthritis. In addition, the potential feasibility of treating OA with GH will be further explored and summarized.

Keywords

growth hormone - cancer - IGF-1 - osteoarthritis - hormone regulation


Publication History

Received: 23 January 2024

Accepted after revision: 01 September 2024

Article published online:
07 November 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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