Recent Advances in Transition-Metal-Catalyzed Enantioconvergent Transformations of Epoxides

Abstract

In recent years, asymmetric ring-opening reactions of epoxides have emerged as a compelling strategy for constructing chiral building blocks in organic synthesis. Among these, transition-metal-catalyzed stereoselective transformations of epoxides have garnered particular attention for their high efficiency and cost-effectiveness. The increasing interest and advancements in this area have spurred exploration into diverse transition-metal catalysts and chiral ligands, highlighting their potential to facilitate a wide range of transformations with enhanced efficiency and flexibility. This short review showcases significant achievements in transition-metal-catalyzed enantioconvergent transformations of epoxides, emphasizing their scope of application and reaction mechanisms.

1 Introduction

2 Palladium-Catalyzed Enantioconvergent Cross-Coupling of Epoxides

3 Nickel-Catalyzed Enantioconvergent Cross-Coupling of Epoxides

4 Titanium-Catalyzed Enantioconvergent Cross-Coupling of Epoxides

5 Iridium-Catalyzed Enantioconvergent Cross-Coupling of Epoxides

6 Cobalt-Catalyzed Enantioconvergent Cross-Coupling of Epoxides

7 Copper-Catalyzed Enantioconvergent Cross-Coupling of Epoxides

8 Conclusions and Outlook

Key words

transition-metal-catalyzed - epoxides - enantioconvergent - cross-coupling - functionalization

Publication History

Received: 30 July 2024

Accepted after revision: 29 October 2024

Accepted Manuscript online:
29 October 2024

Article published online:
25 November 2024

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