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DOI: 10.1055/a-2493-8106
Synthesis of Chiral Cyclopentadienyl Rhodium Complexes and Their Application in Enantioselective C–H Functionalization Reactions
We thank the National Key R&D Program of China (2021YFA1500100), the National Natural Science Foundation of China (21821002, 92256302 and 22071260) for generous financial support. S.-L.Y. acknowledges the support from New Cornerstone Science Foundation.
Abstract
In recent years, rhodium catalysis has evolved as a powerful tool for chemo- and stereocontrolled syntheses of chiral molecules through C–H functionalization. In particular, chiral cyclopentadienyl rhodium (CpRh) complex-catalyzed asymmetric C–H functionalization reactions have gained ever-increasing attention in organic synthesis. However, the design and synthesis of novel chiral Cp ligands remain challenging due to the difficulty of imparting chiral elements into the Cp moiety. In this account, we introduce our research progress in the syntheses of chiral cyclopentadienyl ligands and their applications in rhodium-catalyzed asymmetric C–H functionalization reactions.
1 Introduction
2 SCpRh-Catalyzed Enantioselective C–H Functionalization Reactions
3 CpmRh-Catalyzed Enantioselective C–H Functionalization Reactions
4 BOCpRh-Catalyzed Enantioselective C–H Functionalization Reactions
5 BCSCpRh-Catalyzed Enantioselective C–H Functionalization Reactions
6 Conclusion
Key words
asymmetric catalysis - cyclopentadienyl ligands - C–H functionalization - rhodium catalysisPublication History
Received: 06 November 2024
Accepted after revision: 29 November 2024
Accepted Manuscript online:
29 November 2024
Article published online:
18 December 2024
© 2024. Thieme. All rights reserved
Georg Thieme Verlag KG
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