Spirocyclizations of Nortropanes

In memoriam of Professor Alexander M. Pinchuk

Abstract

The shape-persistent bicyclic nortropane fragment is frequently found in both natural remedies and synthetic drugs. Herein we review synthetic approaches towards spirocyclic nortropanes, as well as their studied stereochemical properties and biological activity.

1 Introduction

2 Spiro Hybrids of Nortropane with Three-Membered Cycles

3 Spiro Hybrids of Nortropane with Four-Membered Cycles

4 Spiro Hybrids of Nortropane with Five-Membered Cycles

5 Spiro Hybrids of Nortropane with Six-Membered and Larger Cycles

6 Conclusions

Key words

nortropane - spiro compounds - cyclization - stereochemistry - biological activity

Publikationsverlauf

Eingereicht: 26. September 2024

Angenommen nach Revision: 16. Dezember 2024

Accepted Manuscript online:
16. Dezember 2024

Artikel online veröffentlicht:
03. Februar 2025

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