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DOI: 10.1055/a-2514-2076
“Standardization of Myocardial Protection: Comment on Cardiac Surgery 2023 Reviewed”
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Standardization of Myocardial Protection: Comment on Cardiac Surgery 2023 Reviewed
We thank the authors for their comments on our recent cardiac surgery reviewed article. They refer to the myocardial protection section in the article which, for space reasons consisted of one small paragraph, which was kept general and cannot address specific aspects. However, we had mentioned in a subclause that current cardioplegia solutions are at least 30 years old. The authors here present their recent work on a new cardioplegic solution that has just received Conformité Européenne certification.[1] We reviewed the field of myocardial protection in a different article earlier, in which we dove into details of mechanisms and outcomes and also illustrated the potential for future developments.[2] At that time we were only aware of the newly approved Custodiol N[3] [4] solution and most of the authors' experiences seem to be published just recently.[5] It is therefore enlightening to realize that cardioplexol has also received approval as a new cardioplegic solution. It will now depend on the market penetration of these two new solutions, whether we will have to revise our statement from above.
Publication History
Received: 13 November 2024
Accepted: 29 November 2024
Article published online:
28 January 2025
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References
- 1 Tevaeara Stahel H, Barandun S, Kaufmann E. et al. Single-center experience with the combination of Cardioplexol™ cardioplegia and MiECC for isolated coronary artery bypass graft procedures. J Thorac Dis 2019; 11 (Suppl. 10) S1471-S1479
- 2 Mukharyamov M, Schneider U, Kirov H, Caldonazo T, Doenst T. Myocardial protection in cardiac surgery-hindsight from the 2020s. Eur J Cardiothorac Surg 2023; 64 (06) ezad424
- 3 Veres G, Radovits T, Merkely B, Karck M, Szabó G. Custodiol-N, the novel cardioplegic solution reduces ischemia/reperfusion injury after cardiopulmonary bypass. J Cardiothorac Surg 2015; 10: 27
- 4 Szabó G, Brlecic P, Loganathan S. et al. Custodiol-N versus Custodiol: a prospective randomized double-blind multicentre phase III trial in patients undergoing elective coronary bypass surgery. Eur J Cardiothorac Surg 2022; 62 (05) ezac287
- 5 Tevaearai HT, WG, Landowski P, Carrel T, Schmidli J, Voet B, Grabenwöger M. A single-centre, single-blind, randomized, active-controlled phase 3 non-inferiority study to investigate the safety and efficacy of the cardioplegic solution Cardioplexol™. Front Cardiovasc Med 2024 ;2024 (Submitted)