First-Row Transition-Metal Catalysis for Organic Synthesis.
Cobalt-Catalyzed Reductive Heck Cyclization Using Water as Hydrogen Donor to Access Oxindoles
Li-Dong Sun
a
College of Chemistry and Chemical Engineering, and Key (Guangdong-Hong Kong Joint) Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong 515063, P. R. of China
,
Qian Xiao∗
b
School of Chemistry and Environmental Engineering, Hanshan Normal University, Chaozhou, Guangdong 521041, P. R. of China
,
Sanliang Li
a
College of Chemistry and Chemical Engineering, and Key (Guangdong-Hong Kong Joint) Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong 515063, P. R. of China
,
Jian-Ji Zhong∗
a
College of Chemistry and Chemical Engineering, and Key (Guangdong-Hong Kong Joint) Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong 515063, P. R. of China
› Author AffiliationsThe project is supported by the National Natural Science Foundation of China (22171177), the Guangdong-Hong Kong Joint Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province (2023B1212120011), the Characteristic Innovation Project of Guangdong Colleges and Universities (2024KTSCX108), the 2022 Scientific Research Start-up Funds of Hanshan Normal University (QD202208), and the Guangdong Basic and Applied Basic Research Foundation (2023A1515110791).
An efficient cobalt-catalyzed intramolecular reductive Heck reaction using water as hydrogen donor for the synthesis of valuable 3,3-disubstituted oxindoles from 2-halo-N-arylacrylamides is described. The approach features operational simplicity and high functional group tolerance. Importantly, when the reaction was performed in D2O, the deuterated oxindoles could be rapidly accessed in a facile and low-cost manner.
