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Synthesis
DOI: 10.1055/a-2774-3054
DOI: 10.1055/a-2774-3054
Paper
Synthesis of the Pentasaccharide Repeating unit Corresponding to the Cell-wall O-antigenic Polysaccharide of Oral Bacteria Porphyromonas circumdentaria NCTC 12469
Authors
Abstract
A concise chemical synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the cell-wall O-antigen of Porphyromonas circumdentaria NCTC 12469, which plays an important role in the development of periodontal disease. Several regio- and stereoselective glycosylations were carried out with high yields and satisfactory stereochemistry at the glycosidic linkages using suitably functionalized thioglycoside intermediates as glycosyl donors.
Publication History
Received: 10 November 2025
Accepted after revision: 10 December 2025
Article published online:
16 January 2026
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