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DOI: 10.1055/s-0028-1082608
© Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
Stellenwert monoklonaler Antikörper und oraler Tyrosinkinase-Inhibitoren in der Therapie des fortgeschrittenen Pankreaskarzinoms
Publication History
Publication Date:
02 October 2008 (online)
Zusammenfassung
Seit etwa einer Dekade gilt die Gemcitabintherapie als international anerkannte Standardbehandlung des fortgeschrittenen Pankreaskarzinoms. In einer Vielzahl von randomisierten Phase-III-Studien konnte bisher kein eindeutiger Überlebensvorteil für eine Gemcitabin-basierte Kombinationschemotherapie gezeigt werden. Vor diesem Hintergrund und basierend auf viel versprechenden präklinischen Daten verfolgen aktuelle Therapieansätze vor allem die Einbeziehung von molekular-gezielten Substanzen in die Therapieprotokolle beim fortgeschrittenen Pankreaskarzinom. Die vorliegende Arbeit gibt einen Überblick über die aktuellen Studiendaten zu monoklonalen Antikörpern und zu oralen Tyrosinkinase-Inhibitoren und zudem auch einen Ausblick über künftige Konzepte der molekularen Patientenselektion beim inoperablen Pankreaskarzinom.
Summary
Since more than 10 years, single-agent gemcitabine is regarded as an international standard of care for patients with advanced pancreatic cancer. So far, several randomized phase III trials failed to show a significant survival benefit for a gemcitabine-based combination chemotherapy regimen. Based on these negative chemotherapy trials and on promising preclinical data, current treatment concepts in advanced pancreatic cancer include the introduction of molecular targeted agents in clinical trials. This review summarizes the currently available data from clinical trials with monoclonal antibodies and oral tyrosine kinase inhibitors and also gives a perspective for molecular-based patient selection concepts in non-resectable pancreatic cancer.
Schlüsselwörter
Antikörper - Chemotherapie - Gemcitabin - Pankreaskarzinom - Tyrosinkinase-Inhibitor
Keywords
Antibody - Chemotherapy - Gemcitabine - Pancreatic Cancer - Tyrosine Kinase Inhibitor
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Korrespondenzadresse
Dr. med. Stefan Böck
Medizinische Klinik und Poliklinik III
Klinikum der
Universität München –
Campus
Großhadern
Marchioninistr. 15
81377 München
Email: stefan.boeck@med.uni-muenchen.de