An Efficient Method for the
Synthesis of α-Hydroxyalkyl Aryl Ketones

Chengqun Chen; Xinghua Feng; Guozhen Zhang; Qin Zhao; Guosheng Huang

doi:10.1055/s-0028-1083149

PAPER

An Efficient Method for the Synthesis of α-Hydroxyalkyl Aryl Ketones

Chengqun Chen, Xinghua Feng, Guozhen Zhang, Qin Zhao, Guosheng Huang*
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
Fax: +86(931)8912582; e-Mail: hgs2368@163.com;

Abstract

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Abstract

Exposure of alkyl aryl ketones to Oxone^®/trifluoroacetic anhydride in the presence of a catalytic amount of iodobenzene affords α-hydroxyalkyl aryl ketones in good yield. This method provides an effective and economical entry for the installation of α-hydroxy moieties into ketones and should find wide application in the construction of the α-hydroxy ketone subunit in natural product synthesis.

Key words

Oxone^® - hydroxylation - iodobenzene - α-hydroxy ketones

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