Synthesis of Indoles via Diethylzinc-Mediated
Intramolecular Hydroamination Reactions of Alkynyl Sulfonamides

Yan Yin; Zhuo Chai; Wen-Ying Ma; Gang Zhao

doi:10.1055/s-0028-1083236

PSP

Synthesis of Indoles via Diethylzinc-Mediated Intramolecular Hydroamination Reactions of Alkynyl Sulfonamides

Yan Yin, Zhuo Chai, Wen-Ying Ma, Gang Zhao*
Laboratory of Modern Synthetic Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, P. R. of China
Fax: +86(21)64166128; e-Mail: zhaog@mail.sioc.ac.cn;

Abstract

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Abstract

A series of indole derivatives were synthesized through the intramolecular hydroamination of alkynyl sulfonamides using 20 mol% of diethylzinc as the catalyst. A tandem cyclization-nucleophilic addition reaction was also possible to afford C2,C3-disubstituted indoles using 120 mol% of diethylzinc.

Key words

diethylzinc - intramolecular hydroamination - alkynyl sulfonamides - cyclizations - tandem reactions

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Referenzen

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