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Synthesis 2009(5): 713-714  
DOI: 10.1055/s-0028-1083348
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Convenient Multigram Synthesis of 4-Chloropyridine-2,6-dicarbonyl ­Dichloride

Kazuhiko Mitsui, Jon R. Parquette*
Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
Fax: +1(614)2921685; e-Mail: parquett@chemistry.ohio-state.edu;
Further Information

Publication History

Received 12 September 2008
Publication Date:
02 February 2009 (online)

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Abstract

A method amenable to the multigram-scale preparation of 4-chloropyridine-2,6-dicarbonyl dichloride is described. The key transformation is the deoxygenative chlorination of the pyridine N-oxide with oxalyl choride.

Key words

4-chloropyridine-2,6-dicarbonyl dichloride - supramolecular chemistry - deoxygenative chlorination - carboxylic acid chlorides - nitrogen heterocycles

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