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Semin Thromb Hemost 2008; 34(4): 373-379
DOI: 10.1055/s-0028-1085480
© Thieme Medical Publishers
DOI: 10.1055/s-0028-1085480
Laboratory Testing for Lupus Anticoagulants: Diagnostic Criteria and Use of Screening, Mixing, and Confirmatory Studies
Further Information
Publication History
Publication Date:
23 September 2008 (online)
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ABSTRACT
The presence of lupus anticoagulants (LA) in plasma is a strong risk factor for thromboembolism and fetal loss. Because of this, demand for testing for LA is increasing, but the performance of clinical laboratories in terms of its detection is still a matter of concern. This is due in part to the lack of specific tests but also to the lack of standardization and application of the diagnostic criteria. The aim of this article is to review the diagnostic criteria and the many issues that may affect test results.
KEYWORDS
Thrombophilia testing - antiphospholipid syndrome - thrombosis - fetal loss
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Dr. Armando Tripodi
Via Pace 9, 20122 Milan
Italy
Email: armando.tripodi@unimi.it