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Synthesis 2009(11): 1801-1806
DOI: 10.1055/s-0028-1088074
DOI: 10.1055/s-0028-1088074
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Microwave-Promoted Solid-Acid-Catalyzed One-Pot Synthesis of Phthalazinones
Further Information
Publication History
Received
22 December 2008
Publication Date:
27 April 2009 (online)


Abstract
A one-pot, solid-acid-catalyzed, microwave-assisted synthesis of phthalazinones is described. The commercially available montmorillonite K-10 effectively catalyzed the condensation and substitution reactions. The approach was based on the direct cyclization of phthalaldehydic acid and opianic acid with substituted hydrazines. The reactions provided excellent yields and high selectivities in very short time (5-35 minutes).
Key words
phthalazinones - phthalaldehydic acid - opianic acid - hydrazines - montmorillonite K-10 - microwave heating