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Synthesis 2009(11): 1801-1806  
DOI: 10.1055/s-0028-1088074
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Microwave-Promoted Solid-Acid-Catalyzed One-Pot Synthesis of Phthalazinones

Verona M. Outerbridge, Shainaz M. Landge, Hiroko Tamaki, Béla Török*
Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA 02125, USA
Fax: +1(617)2876030; e-Mail: bela.torok@umb.edu;
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Publication History

Received 22 December 2008
Publication Date:
27 April 2009 (online)

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Abstract

A one-pot, solid-acid-catalyzed, microwave-assisted synthesis of phthalazinones is described. The commercially available montmorillonite K-10 effectively catalyzed the condensation and substitution reactions. The approach was based on the direct cyclization of phthalaldehydic acid and opianic acid with substituted hydrazines. The reactions provided excellent yields and high selectivities in very short time (5-35 minutes).

Key words

phthalazinones - phthalaldehydic acid - opianic acid - hydrazines - montmorillonite K-10 - microwave heating

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