Use of ‘Click Chemistry’ for the Synthesis of Tetrazole-Containing Analogues of the Neuroprotective Agent Glycyl-l-prolyl-l-glutamic Acid

Abstract

Tetrazole-containing analogues of glycyl-l-prolyl-l-glutamic acid (GPE) were prepared by coupling of Cbz-glycyl-l-proline with tetrazole-containing glutamic acids followed by hydrogenation of the resultant tripeptide. Synthesis of the tetrazole-­containing glutamic acids involved 1,3-dipolar cycloaddition of ­sodium azide to nitrile derivatives of the corresponding glutamic ­acids.

Key words

GPE - 1,3-dipolar cycloaddition - tetrazole - TMSI - BoPCl

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