Planta Med 2009; 75(1): 80-83
DOI: 10.1055/s-0028-1088359
Natural Products Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Two New Adjacent Bis-Tetrahydrofuran Annonaceous Acetogenins from Seeds of Annona cornifolia

Luciana Alves Rodrigues dos Santos Lima1 , Lúcia Pinheiro Santos Pimenta1 , Maria Amélia Diamantino Boaventura1
  • 1Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Further Information

Publication History

Received: April 9, 2008 Revised: September 5, 2008

Accepted: September 10, 2008

Publication Date:
27 November 2008 (online)

Abstract

Two new adjacent bis-THF annonaceous acetogenins, 9-hydroxyfolianin (1) and folianin B (2), together with two known acetogenins, asimicin (3) and bullatacin (4), significantly bioactives in brine shrimp lethality test, were isolated from seeds of Annona cornifolia A. St. Hil (Annonaceae). Their structures were elucidated by NMR and ESI-MS analysis, and relative configurations were established. The absolute configuration around the THF rings of 1 was defined by Mosher esters methodology and circular dichroism.

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Prof. Dr. Maria Amélia Diamantino Boaventura

Departamento de Química

Instituto de Ciências Exatas

Universidade Federal de Minas Gerais

Av. Antônio Carlos 6627

Belo Horizonte, 31 270901 Minas Gerais

Brazil

Phone: +55-31-3409-5760

Fax: +55-31-3409-5700

Email: dianadb@netuno.lcc.ufmg.br