Planta Med 2009; 75(1): 55-58
DOI: 10.1055/s-0028-1088361
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Studies on the Antihyperlipidemic Properties of Averrhoa bilimbi Fruit in Rats

Savithri Ambili1 , Appian Subramoniam1 , Natesan Shanmugam Nagarajan2
  • 1Department of Phytochemistry and Phytopharmacology, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram, Kerala State, India
  • 2Gandhigram Rural University, Gandhigram, Tamilnadu, India
Further Information

Publication History

Received: January 14, 2008 Revised: September 3, 2008

Accepted: September 8, 2008

Publication Date:
24 November 2008 (online)

Abstract

Averrhoa bilimbi Linn. fruit and its extracts were screened for antihypercholesterolemic activity using Triton-induced hypercholesterolemia in rats as a model. The fruit and its water extract, but not alcohol and hexane extracts, showed remarkable antihypercholesterolemic activity. An active fraction, which showed activity at a low dose of 0.8 mg/kg, was purified from the water extract. An active component was isolated from the active fraction, which showed optimum activity at a dose of 0.3 mg/kg. The efficacy of the fruit was tested in chronic high-fat diet fed hyperlipidemic rats. The fruit (125 mg/kg) as well as its water extract (50 mg/kg) were found to be effective in lowering lipids in the high-fat diet fed rats. The fruit was subjected to preliminary general toxicity evaluation in mice. Oral administration of the fruit homogenate daily for 15 days did not result in any toxic symptoms up to a dose of 1 g/kg studied. Thus, this fruit can be used as a dietary ingredient to prevent as well as treat hyperlipidemia.

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Dr. A. Subramoniam

Department of Phytochemistry and Phytopharmacology

Tropical Botanic Garden and Research Institute

Palode

Thiruvananthapuram 695562

Kerala State

India

Phone: +91-(0)472-286-9226

Fax: +91-(0)472-286-9646

Email: asubramoniam@yahoo.com