Zusammenfassung
Die Markierung von Gewebestrukturen im hinteren Augensegment hat sich in den vergangenen 8 Jahren zu einem etablierten Bestandteil der vitreoretinalen Chirurgie entwickelt. In dieser Zusammenfassung wird ein Überblick über derzeitig verfügbare Markierungs- und Farbstoffe sowie deren operative Anwendung vermittelt.
Abstract
Staining of intraocular tissue has become an established tool of vitreoretinal procedures within the last 8 years. This review describes the presently available dyes and markers and their use during vitreoretinal procedures.
Schlüsselwörter
Vitalfarbstoffe - Brilliant Blue G - Indocyaningrün - Trypan Blau - Patent Blau - Retina - Vitrektomie - Lamina limitans interna
Key words
vital dyes - brilliant blue G - indocyanin green - trypan blue - patent blue - retina - vitrectomy - internal limiting membrane
Literatur
-
1
Abrams G W, Topping T, Machemer R.
An improved method for practice vitrectomy.
Arch Ophthalmol.
1978;
96
521-525
-
2
Ando F, Sasano K, Ohba N. et al .
Anatomic and visual outcomes after indocyanine green-assisted peeling of the internal limiting membrane in idiopathic macula hole surgery.
Am J Ophthalmol.
2004;
137
744-746
-
3
Burk S E, da Mata A P, Snyder M E. et al .
Indocyanine green-assisted peeling of the retinal internal limiting membrane.
Ophthalmology.
2000;
107
2010-2014
-
4
Burk S E, Da Mata A P, Snyder M E. et al .
Visualizing vitreous using Kenalog suspension.
J Cataract Refract Surg.
2003;
29
645-651
-
5
Cevera E, Diaz Llopis M, Salom D. et al .
Internal limiting membrane staining using intravitreal brilliant blue G: good help for vitreo-retinal surgeon in training.
Arch Soc Esp Oftalmol.
2007;
82
71-72
-
6
Doi N, Uemura A, Nakao K. et al .
Vitreomacular adhesion and the defect in posterior vitreous cortex visualized by triamcinolone-assisted vitrectomy.
Retina.
2005;
25
742-745
-
7
Enaida H, Hiatomi T, Goto Y. et al .
Preclinical investigation of internal limiting membrane staining and peeling using intravitreal brilliant blue G.
Retina.
2006;
26
623-630
-
8
Enaida H, Hisatomi T, Hata Y. et al .
Brilliant Blue G selectively stains the internal limiting membrane/Brilliant Blue G-assisted membrane peeling.
Retina.
2006;
26
631-636
-
9
Engel E, Schraml R, Maisch T. et al .
Light-induced decomposition of indocyanine green.
Invest Ophthalmol Vis Sci.
2008;
49
1777-1783
-
10
Gandorfer A, Haritoglou C, Gass C A. et al .
Indocyanin green-assisted peeling of the internal limiting membrane may cause retinal damage.
Am J Ophthalmol.
2001;
132
431-433
-
11
Gass C A, Haritoglou C, Schaumberger M. et al .
Functional outcome of macular hole surgery with and without indocyanine green-assisted peeling of the internal limiting membrane.
Graefes Arch Clin Exp Ophthalmol.
2003;
24
716-720
-
12
Guo S, Tuela A C, Wagner R. et al .
A comparison of the effectiveness of four biostains in enhancing visualization of the vitreous.
J Pediatr Ophthalmol Strabismus.
2006;
43
281-284
-
13
Haritoglu C, Gandorfer A, Gass C A. et al .
The effect of indocyanine-green on functional outcome of macular pucker surgery.
Am J Ophthamol.
2003;
135
328-337
-
14
Haritoglu C, Yu A, Freyer W. et al .
An evaluation of novel vital dyes for intraocular surgery.
Invest Ophthalmol Vis Sci.
2005;
46
3315-3322
-
15
Haritoglu C, Tadayoni R, May C A. et al .
Short-term in vivo evaluation of novel vital dys for intraocular surgery.
Retina.
2006;
26
673-678
-
16
Haritoglu C, Schumann R G, Strauss R. et al .
Vitreoretinal surgery using bromphenol blue as a vital stain: evaluation of staining characteristics in humans.
Br J Ophthalmol.
2007;
91
1125-1128
-
17
Hasler P W, Prünte C.
Early foveal recovery after macular hole surgery.
Br J Ophthalmol.
2008;
92
645-649
-
18
Hata Y, Enaida H, Sassa Y. et al .
Preclinical investigation of fluorometholone acetate as a potential new adjuvant during vitreous surgery.
Graefes Arch Clin Exp Ophthalmol.
2007;
245
1019-1025
-
19
Hiebl W, Günther B, Meinert H.
Substanzen zur Anfärbung von biologischem Gewebe – Farbstoffe in der Augenheilkunde.
Klin Mbl Augenheilkd.
2005;
222
309-311
-
20
Hillenkamp J, Saikia P, Herrmann W A. et al .
Surgical removal of idiopathic epiretinal membrane with or without the assistance of indocyanine green: a randomised controlled clinical trial.
Graefes Arch Clin Exp Ophthalmol.
2007;
245
973-979
-
21
Iriyama A, Uchida S, Yanagi Y. et al .
Effects of indocyanine green on retinal ganglion cells.
Invest Ophthalmol Vis Sci.
2004;
45
943-947
-
22
Jackson T L, Hillenkamp J, Knight B C. et al .
Safety testing of indocyanin green and trypan blue using retinal pigment epithelium and glial cell cultures.
Invest Ophthalmol Vis Sci.
2004;
45
2778-2785
-
23
Jackson T L, Griffin L, Vote B. et al .
An experimental method for testing novel retinal vital stains.
Exp Eye Res.
2005;
81
446-454
-
24
Jin Y, Uchida S, Yanagi Y. et al .
Neurotoxic effects of trypan blue on rat retinal ganglion cells.
Exp Eye Res.
2005;
81
395-400
-
25
Jonas J B, Kreissig I, Degenring R.
Intravitreal triamcinolone acetonide for treatment of intraocular proliferative, exsudative, and neovascular diseases.
Prog Retina Eye Res.
2005;
24
587-611
-
26
Kunikata H, Abe T, Sagara Y. et al .
Hypthermia of 8 °C protects cultured retinal pigment epithelial cells and retinal ganglion cells against trypan blue toxcicity.
Am J Ophthalmol.
2006;
141
754-756
-
27
Lochhead J, Jones E, Chui D. et al .
Outcome of ICG-assisted ILM peel in macular hole surgery.
Eye.
2004;
18
804-808
-
28
Lüke C, Lüke M, Dietlein T S. et al .
Retinal tolerance to dyes.
Br J Ophthalmol.
2005;
89
1188-1191
-
29
Lüke C, Lüke M, Sickel W. et al .
Effects of patent blue on human retinal function.
Graefe’s Arch Clin Exp Ophthalmol.
2006;
244
1188-1190
-
30
Maia M, Haller J A, Pieramici D J. et al .
Retinal pigment epithelium abnormalities after internal limiting membrane peeling guided by indocyanine green staining.
Retina.
2004;
24
157-160
-
31
Maia M, Lenner L, deJuan E. et al .
Effects of indocyanin green delivery over the retinal surface and into the subretinal space in rabbits.
Retina.
2004a;
24
80-91
-
32
Maia M, Margalit E, So M OM. et al .
Effects of intravitreal indocyanin green injection in rabbits.
Retina.
2004b;
24
69-79
-
33
Maia M, Penha F, Rodrigues E B. et al .
Effects of subretinal injection of patent blue and trypan blue in rabbits.
Curr Eye Res.
2007;
32
309-317
-
34
Mennel S, Meyer C H, Tietjen A. et al .
Patent blue: a novel vital dye in vitreoretinal surgery.
Ophthalmologica.
2006;
220
190-193
-
35
Mennel S, Thumann G, Peter S. et al .
Einfluss von Vitalfarbstoffen auf die Funktion der äußeren Blut-Retina-Schranke in vitro.
Klin Mbl Augenheilkd.
2006a;
223
568-576
-
36
Morrison V L, Koh H J, Cheng L. et al .
Intravitreal toxicity of the kenalog vehicle (benzyl alcohol) in rabbits.
Retina.
2006;
26
339-344
-
37
Narayanan R, Kenney M C, Kamjoo S. et al .
Trypan Blue: Effect of retinal pigment epithelial and neurosensory retinal cells.
Invest Ophthalmol Vis Sci.
2005;
46
304-309
-
38
Penha F, Maia M, Farah M E. et al .
Effects of subretinal injections of indocyanine green, trypan blue, and glucose in rabbit eyes.
Ophthalmology.
2007;
114
899-908
-
39
Rodrigues E B, Meyer C H, Kroll P.
Chromovitrectomy: a new field in vitreoretinal surgery.
Graefes Arch Clin Exp Ophthalmol.
2005;
243
291-293
-
40
Rodrigues E B, Meyer C H.
Meta-analysis of chromovitrectomy with indocyanin green in macular hole surgery.
Ophthalmologica.
2008;
222
123-129
-
41
Ruiz-Moreno J M, Montero J A, Bayon A. et al .
Retinal toxicity of intravitreal triamcinolone acetonide at high doses in the rabbit.
Exp Eye Res.
2007;
84
342-348
-
42
Schuettauf F, Haritoglou C, May C A. et al .
Administration of novel dyes for intraocular surgery: an in vivo toxicity animal study.
Invest Ophthalmol Vis Sci.
2006;
47
3573-3578
-
43
Schumann R G, Remy M, Grueterich M. et al .
How it appears: electron microscopic evaluation of internal limiting membrane specimens obtained during brilliant blue G assisted macular hole surgery.
Br J Ophthalmol.
2008;
92
330-331
-
44
Shah G K, Rosenblatt B J, Blinder K J. et al .
Triamcinolone-assisted internal limiting membrane peeling.
Retina.
2005;
25
972-975
-
45
Sheidow T G, Blinder K J, Holekamp N. et al .
Outcome results in macular hole surgery: an evaluation of internal limiting membrane peeling with and without indocyanine green.
Ophthalmology.
2003;
110
1697-1701
-
46
Slaughter K, Lee I L.
Macular hole surgery with and without indocyanin green assistance.
Eye.
2004;
8
376-278
-
47
Teba F A, Mohr A, Eckhardt C. et al .
Trypan blue staining in vitreoretinal surgery.
Ophthalmology.
2003;
110
2409-2412
-
48
Ueno A, Hisatomi T, Enaida H. et al .
Biocompatibility of brilliant blue G in a rat model of subretinal injection.
Retina.
2007;
27
499-504
-
49
Uno F, Malerbi F, Maia M. et al .
Subretinal trypan blue migration during epiretinal membrane peeling.
Retina.
2006;
26
237-239
-
50
Veckenmeer M, Overdam van K, Monzer J. et al .
Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes.
Graefes Arch Clin Exp Ophthalmol.
2001;
239
698-704
-
51
Vote B J, Russel M K, Joondeph B C.
Trypan blue-assisted vitrectomy.
Retina.
2004;
24
736-738
Prof. Dr. Heinrich Gerding, FEBO
Abteilung für Retinologie, Klinik Pallas
Louis-Giroud-Str. 20
4600 Olten
Schweiz