Giant-Cell Tumors of the Temporal Bone: Management Strategies

ABSTRACT

Objective: To discuss the current management options for giant-cell tumors (GCTs) involving the temporal bone and present two case reports and a review of the literature. Method: In a tertiary-care academic medical center, two patients with GCTs of the temporal bone were evaluated and managed. The patients underwent gross total resection and curettage of GCTs involving the temporal bone. Afterward, both patients were evaluated for postoperative complications as well as for recurrence. Results: Two patients underwent operative excision using curettage. Clinical and radiographic studies demonstrated no evidence of recurrence with 3 years of follow-up in one patient and 10 years of follow-up in the second patient. Conclusion: Based on these results, we concluded that gross total removal and curettage of GCTs in the temporal bone is a viable treatment option. This finding is contrary to previous studies.

Temporal bone - giant-cell tumors - skull base

REFERENCES

• 1 Glasscock III M E, Hunt W E. Giant-cell tumor of the sphenoid and temporal bones.  Laryngoscope. 1974;  84 1181-1187
• 2 Lee H J, Lum C. Giant-cell tumor of the skull base.  Neuroradiology. 1999;  41 305-307
• 3 Meyerhoff W L, Stringer S P, Roland P S. Rambo procedure: modification and application.  Laryngoscope. 1988;  98 795-796
• 4 Murphey M D, Nomikos G C, Flemming D J, Gannon F H, Temple H T, Kransdorf M J. From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation.  Radiographics. 2001;  21 1283-1309
• 5 Doderlein W. Zur Kenntnis der Sarkome des Mittelohors bezw. Des Feisenbeines.  Arch f Ohrenheilk. 1913;  92 124
• 6 Bertoni F, Unni K K, Beabout J W, Ebersold M J. Giant cell tumor of the skull.  Cancer. 1992;  70 1124-1132
• 7 Leonard J, Gokden M, Kyriakos M, Derdeyn C P, Rich K M. Malignant giant-cell tumor of the parietal bone: case report and review of the literature.  Neurosurgery. 2001;  48 424-429
• 8 Saleh E A, Taibah A K, Naguib M et al.. Giant cell tumor of the lateral skull base: a case report.  Otolaryngol Head Neck Surg. 1994;  111 314-318
• 9 Rock J P, Mahmood A, Cramer H B. Giant cell tumor of the skull base.  Am J Otol. 1994;  15 268-272
• 10 Colclasure J B, Shea Jr M C, Graham S S. Giant cell lesions of the temporal bone.  Am J Otol. 1981;  2 188-192
• 11 Huvos A. Bone Tumors: Diagnosis, Treatment and Prognosis. Philadelphia; WB Saunders 1991: 469
• 12 Jaffe H L. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jawbones.  Oral Surg Oral Med Oral Pathol. 1953;  6 159-175
• 13 Boedeker C C, Kayser G, Ridder G J, Maier W, Schipper J. Giant-cell reparative granuloma of the temporal bone: a case report and review of the literature.  Ear Nose Throat J. 2003;  82 926-929
• 14 Ung F, Li K K, Keith D A, McKenna M J. Giant cell reparative granuloma of the temporal bone: case report and review of the literature.  Otolaryngol Head Neck Surg. 1998;  118 525-529
• 15 Williams J C, Thorell W E, Treves J S, Fidler M E, Moore G F, Leibrock L G. Giant cell reparative granuloma of the petrous temporal bone: a case report and literature review.  Skull Base Surg. 2000;  10 89-93
• 16 Prosser G H, Baloch K G, Tillman R M, Carter S R, Grimer R J. Does curettage without adjuvant therapy provide low recurrence rates in giant-cell tumors of bone?.  Clin Orthop Relat Res. 2005;  (435) 211-218
• 17 Emley W E. Giant cell tumor of the sphenoid bone: a case report and review of the literature.  Arch Otolaryngol. 1971;  94 369-374
• 18 Wulling M, Engels C, Jesse N, Werner M, Delling G, Kaiser E. The nature of giant cell tumor of bone.  J Cancer Res Clin Oncol. 2001;  127 467-474
• 19 Swartz J. Imaging of the Temporal Bone. New York; Thieme Medical Publishers 1992: 48
• 20 Dickson B C, Li S Q, Wunder J S et al.. Giant cell tumor of bone express p63.  Mod Pathol. 2008;  21 369-375
• 21 Antal I, Sápi Z, Szendroi M. The prognostic significance of DNA cytophotometry and proliferation index (Ki-67) in giant cell tumors of bone.  Int Orthop. 1999;  23 315-319
• 22 Bertoni F, Bacchini P, Staals E L. Malignancy in giant cell tumor of bone.  Cancer. 2003;  97 2520-2529
• 23 Manaster B J, Doyle A J. Giant cell tumors of bone.  Radiol Clin North Am. 1993;  31 299-323
• 24 Larsson S E, Lorentzon R, Boquist L. Giant-cell tumor of bone: a demographic, clinical, and histopathological study of all cases recorded in the Swedish Cancer Registry for the years 1958 through 1968.  J Bone Joint Surg Am. 1975;  57 167-173
• 25 O'Donnell R J, Springfield D S, Motwani H K, Ready J E, Gebhardt M C, Mankin H J. Recurrence of giant-cell tumors of the long bones after curettage and packing with cement.  J Bone Joint Surg Am. 1994;  76 1827-1833
• 26 Blackley H R, Wunder J S, Davis A M, White L M, Kandel R, Bell R S. Treatment of giant-cell tumors of long bones with curettage and bone-grafting.  J Bone Joint Surg Am. 1999;  81 811-820
• 27 Nair S B, Abou-Elhamd K A, Hawthorne M. A retrospective analysis of high resolution computed tomography in the assessment of cochlear implant patients.  Clin Otolaryngol Allied Sci. 2000;  25 55-61
• 28 Malone S, O'Sullivan B, Catton C, Bell R, Fornasier V, Davis A. Long-term follow-up of efficacy and safety of megavoltage radiotherapy in high-risk giant cell tumors of bone.  Int J Radiat Oncol Biol Phys. 1995;  33 689-694
• 29 Lee M Y, Lee E J. Giant cell tumor of the petrous temporal bone with direct invasion into the middle ear.  J Craniofac Surg. 2006;  17 797-800