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DOI: 10.1055/s-0029-1185316
© Georg Thieme Verlag KG Stuttgart · New York
The Flavonoid Rutin but not the Alkaloid Arborinine Induces Apoptosis in a B-Cell Hybridoma Cell Line
Publication History
received April 6, 2008
revised Dec. 1, 2008
accepted Dec. 7, 2008
Publication Date:
20 February 2009 (online)
Abstract
The effects of arborinine, an alkaloid extracted from Erthela bahiensis and of rutin, a flavonoid obtained from Dimorphandra mollis (Benth.), Brazilian medicinal plants, on the viability and function of a murine B-cell hybridoma as a tumor model were investigated. The flavonoid rutin at 50 µΜ induced an increase in the number of apoptotic cells of one- to fivefold and reductions in cellular proliferation and monoclonal antibody production. Less but still significant necrosis was also induced by rutin under the same experimental conditions. On the other hand, the alkaloid arborinine exerted no significant effects on the studied parameters.
Key words
Erthela bahiensis - Rutaceae - Dimorphandra mollis - Leguminosae - arborinine - rutin
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