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Planta Med 2009; 75(5): 488-493
DOI: 10.1055/s-0029-1185316
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

The Flavonoid Rutin but not the Alkaloid Arborinine Induces Apoptosis in a B-Cell Hybridoma Cell Line

Renata Roseghini1 , 2 , Georgenes Morato Falcão1 , José Fernando Oliveira Costa3 , Jorge Clarêncio3 , Ivana Nascimento1 , Eudes Velozo4 , Robert Schaer1 , Vera Vale1 , Silvia Lima Costa5 , Maria de Fátima Dias Costa5 , Marcienne Tardy6 , Roberto Meyer1 , Songelí Menezes Freire1 , 2
  • 1Immunology and Molecular Laboratory (Labimuno), Federal University of Bahia, BA, Brazil
  • 2Escola Bahiana de Medicina e Saúde Pública (EBMSP), BA, Brazil
  • 3Oswaldo Cruz Foundation (CPqGM – FIOCRUZ), BA, Brazil
  • 4LAPEMM, Pharmacy Faculty-Federal University of Bahia, BA, Brazil
  • 5Laboratory of Neurochemical and Cellular Biology, Federal University of Bahia, BA, Brazil
  • 6Inserm, Université de Paris XII, Paris, France
Further Information

Publication History

received April 6, 2008 revised Dec. 1, 2008

accepted Dec. 7, 2008

Publication Date:
20 February 2009 (online)

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Abstract

The effects of arborinine, an alkaloid extracted from Erthela bahiensis and of rutin, a flavonoid obtained from Dimorphandra mollis (Benth.), Brazilian medicinal plants, on the viability and function of a murine B-cell hybridoma as a tumor model were investigated. The flavonoid rutin at 50 µΜ induced an increase in the number of apoptotic cells of one- to fivefold and reductions in cellular proliferation and monoclonal antibody production. Less but still significant necrosis was also induced by rutin under the same experimental conditions. On the other hand, the alkaloid arborinine exerted no significant effects on the studied parameters.

Key words

Erthela bahiensis - Rutaceae - Dimorphandra mollis - Leguminosae - arborinine - rutin

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Prof. Renata Roseghini

Instituto de Ciências da Saúde

Av. Reitor Miguel Calmon S/N

Vale do Canela

CEP: 40

110–100 Salvador

Bahia

Brazil

Phone: + 55 71 33 69 02 08

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