Planta Med 2009; 75(5): 543-546
DOI: 10.1055/s-0029-1185320
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Bicyclononane Aldehydes and Antiproliferative Constituents from Amomum tsao-ko

Xinzhou Yang1 , Peter Küenzi1 , Inken Plitzko1 , Olivier Potterat1 , Matthias Hamburger1
  • 1Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland
Further Information

Publication History

received October 21, 2008 revised December 4, 2008

accepted December 8, 2008

Publication Date:
04 February 2009 (online)

Abstract

A racemic mixture of a new bicyclononane aldehyde, (1RS,5SR,6RS)-5-hydroxybicyclo[4.3.0]non-2-ene-2-carbaldehyde (1) was isolated from the fruits of Amomum tsao-ko, together with 12 known compounds (213). The structure of 1 was determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR data. The antiproliferative activity of compounds 113 was assessed in the murine neuroblastoma cell line N2a.

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Prof. Dr. Matthias Hamburger

Institute of Pharmaceutical Biology
University of Basel

Klingelbergstrasse 50

4056 Basel

Switzerland

Phone: + 41 6 12 67 14 25

Fax: + 41 6 12 67 14 74

Email: matthias.hamburger@unibas.ch