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DOI: 10.1055/s-0029-1185328
© Georg Thieme Verlag KG Stuttgart · New York
Antimicrobial Pentacyclic Triterpenoids from Terminalia superba
Publication History
received August 29, 2008
revised Dec. 8, 2008
accepted Dec. 11, 2008
Publication Date:
12 February 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/200905/lookinside/thumbnails/10.1055-s-0029-1185328-1.jpg)
Abstract
Antibacterial bioassay-guided fractionation of the methanol extract of the stem bark of Terminalia superba led to the isolation of four new triterpene glucosides (1–4) which were characterized as 2α,3β-dihydroxyolean-12-en-28-oic acid 28-O-β-D-glucopyranoside (1), 2α,3β, 21β-trihydroxyolean-12-en-28-oic acid 28-O-β-D-glucopyranoside (2), 2α,3β, 29-trihydroxyolean-12-en-28-oic acid 28-O-β-D-glucopyranoside (3) and 2α,3β,23,27-tetrahydroxyolean-12-en-28-oic acid 28-O-β-D-glucopyranoside (4) together with the known triterpene 2α,3β,23-trihydroxyolean-12-en-28-oic acid (5). Structures were established by spectroscopic methods including one- and two-dimensional NMR, EI‐MS and HR‐EI‐MS. The antibacterial activity of 1–5 was also investigated against two gram-positive (Bacillus subtilis, Staphylococcus aureus), and four gram-negative (Escherichia coli, Shigella flexenari, Pseudomonas aeruginosa, Salmonella typhi) bacterial strains.
Key words
Terminalia superba - Combretaceae - triterpenoids - antibacterial activity
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Prof. Marie-Aleth Lacaille-Dubois
Laboratoire de Pharmacognosie
UMIB UPRES EA 3 660
Faculté de Pharmacie
Université de Bourgogne
7 Bd Jeanne d'Arc
B. P. 87900
21079 Dijon cedex
France
Phone: + 33 3 80 39 32 29
Fax: + 33 3 80 39 33 00
Email: m-a.lacaille-dubois@u-bourgogne.fr