Antioxidant Lignans from Mananthes patentiflora

Abstract

A new tetrahydrofuranoketone lignan (1) and two new tetrahydrofuranoketone lignan glycosides (2, 3) were isolated from the ethanol extract of the aerial part of Mananthes patentiflora. The structure elucidations of these compounds were mainly established on the basis of 1D, 2D NMR and HR-mass spectroscopic analysis. All three compounds revealed potent antioxidant activities within the concentration range tested (0.08–50.0 µM).

Mananthes patentiflora - Acanthaceae - tetrahydrofuranoketone lignans - antioxidant activity

References

• 1 Patrice A M, Massuo J K, Norman G L. (+)-Episesaminone, a Sesamum indicum furofuran lignan. Isolation and hemisynthesis.  J Nat Prod. 1997;  60 1189-1192
• 2 Chenchugari S, Karumanchi V R, Gottumukkala V S. Flavonoids, triterpenoids and a lignan from Vitex altissima.  Phytochemistry. 2005;  66 1707-1712
• 3 Yu H S, Chen C C, Shieh B J. Two new constituents from the leaves of Magnolia coco.  J Nat Prod. 1998;  61 1017-1019
• 4 Jung K Y, Kim D S, Oh S R, Park S H, Lee I S, Lee J J, Shin D H, Lee H K. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii.  J Nat Prod. 1998;  61 808-811
• 5 Andrew T M, Maioli L C, Bruce M F, Dana M G. Asymmetric synthesis of sesaminone: confirmation of its structure and determination of its absolute configuration.  J Org Chem. 1997;  62 7413-7417
• 6 Li N, Jia A Q, Liu Y Q, Zhou J. Two new cycloartane-type triterpene glycosides from Curculigo orchioides.  Acta Bot Yunn. 2003;  25 241-244
• 7 Ghada S N, Musa H AZ, Salim S S, Dawud M AE. Chemical constituents of the flora of Jordan, part III. Mono-O-acetyl diphyllin apioside, a new arylnaphthalene lignan from Haplophyllum buxaumii.  J Nat Prod. 1987;  50 748-750
• 8 Giuma M S, Karima M AA. Lignans of Haplophyllum tuberculatum.  Phytochemistry. 1984;  23 151-153
• 9 Sang B K, Ju Y B, Bo Y L, Yeon H S. Protective effects of fangchinoline and tetrandrine on hydrogen peroxide-induced oxidative neuronal cell damage in culture rat cerebellar granule cells.  Planta Med. 2003;  69 506-512
• 10 Yang X W, Zhao P J, Ma Y L, Xiao H T, Zuo Y Q, He H P, Li L, Hao X J. Mixed lignan-neolignans from Tarenna attenuata.  J Nat Prod. 2007;  70 521-525