Planta Med 2009; 75(12): 1351-1355
DOI: 10.1055/s-0029-1185575
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Three New Alkaloids from Galanthus nivalis and Galanthus elwesii

Strahil Berkov1 , María Cuadrado1 , Edison Osorio1 , Francesc Viladomat1 , Carles Codina1 , Jaume Bastida1
  • 1Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain
Further Information

Publication History

received November 14, 2008 revised February 27, 2009

accepted March 9, 2009

Publication Date:
20 April 2009 (online)

Abstract

Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3′-O-(3′,3′′-dihydroxybutanoyl)hamayne and 11,3′-O-(3′,3′′-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3′-hydroxybutanoyl)lycorine from G. elwesii. Additionally, 3,11-O-(3′,3′′-dihydroxybutanoyl)hamayne, 3,11,3′-O-(3′,3′′,3′′′-trihydroxybutanoyl)hamayne, 8-O-demethylvasconine, tazettine, epimacronine, and ismine from G. nivalis; 2-O-(3′-acetoxybutanoyl)lycorine and incartine from G. elwesii; and hamayne, 11-O-(3′-hydroxybutanoyl)hamayne and lycorine from both species were isolated. Their structures were determined by EI‐MS, HR‐MS, CD, and 1D and 2D NMR (COSY, NOESY, HMQC, and HMBC) experiments.

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Prof. Dr. Jaume Bastida

Departament de Productes Naturals, Biologia Vegetal i Edafologia
Facultat de Farmàcia
Universitat de Barcelona

Av. Joan XXIII s/n

08028 Barcelona

Spain

Phone: + 34 9 34 02 02 68

Fax: + 34 9 34 02 90 43

Email: jaumebastida@ub.edu