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Planta Med 2009; 75(12): 1326-1330
DOI: 10.1055/s-0029-1185687
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Antimycobacterial Activity of Exocarpos latifolius is due to Exocarpic Acid

Michael Koch1 , Tim S. Bugni2 , Chris D. Pond1 , Mohammad Sondossi3 , Manah Dindi4 , Pius Piskaut5 , Chris M. Ireland2 , Louis R. Barrows1
  • 1Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA
  • 2Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA
  • 3Department of Microbiology, Weber State University, Ogden, Utah, USA
  • 4Discipline of Pharmacy, School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea, N. C. D.
  • 5Discipline of Botany, School of Natural and Physical Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea, N. C. D.
Further Information

Publication History

received Nov. 11, 2008 revised March 12, 2009

accepted March 21, 2009

Publication Date:
14 May 2009 (online)

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Abstract

Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.

Key words

Mycobacterium tuberculosis - Exocarpos latifolius - Santalaceae - exocarpic acid - polyacetylenic fatty acids

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Prof. Dr. Louis R. Barrows

Department of Pharmacology and Toxicology
University of Utah

30 S., 2000 E.

Salt Lake City, UT 84112

USA

Phone: + 1 80 15 81 45 47

Email: louis.barrows@pharm.utah.edu