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DOI: 10.1055/s-0029-1185687
© Georg Thieme Verlag KG Stuttgart · New York
Antimycobacterial Activity of Exocarpos latifolius is due to Exocarpic Acid
Publication History
received Nov. 11, 2008
revised March 12, 2009
accepted March 21, 2009
Publication Date:
14 May 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/200912/lookinside/thumbnails/10.1055-s-0029-1185687-1.jpg)
Abstract
Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.
Key words
Mycobacterium tuberculosis - Exocarpos latifolius - Santalaceae - exocarpic acid - polyacetylenic fatty acids
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