Antimycobacterial Activity of Exocarpos latifolius is due to Exocarpic Acid

Abstract

Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.

Key words

Mycobacterium tuberculosis - Exocarpos latifolius - Santalaceae - exocarpic acid - polyacetylenic fatty acids

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