Planta Med 2010; 76(3): 278-283
DOI: 10.1055/s-0029-1186065
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Japonicones E–L, Dimeric Sesquiterpene Lactones from Inula japonica Thunb.

Jiang Jiang Qin1 , Hui Zi Jin1 , Jia Xian Zhu1 , Jian Jun Fu1 , Xiao Jia Hu1 , Xiao Hua Liu2 , Yan Zhu1 , Shi Kai Yan1 , Wei Dong Zhang1 , 2
  • 1School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China
  • 2Department of Phytochemistry, Second Military Medical University, Shanghai, PR China
Further Information

Publication History

received April 17, 2009 revised July 22, 2009

accepted July 27, 2009

Publication Date:
09 September 2009 (online)

Abstract

Eight new dimeric sesquiterpene lactones (japonicones E–L, 18), including a novel sesquiterpene dimer bearing a rare hydroperoxide group (japonicone E, 1), were isolated from the aerial part of Inula japonica Thunb. Their structures were determined mainly by the use of 1D and 2D NMR spectroscopic techniques including HSQC, 1H-1H COSY, HMBC, and NOESY. All the isolates were tested for inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Among the compounds tested, japonicone F (2) showed the strongest activity with the IC50 value of 4.1 µg/mL.

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Dr. Hui Zi Jin
Wei Dong Zhang

School of Pharmacy
Shanghai Jiao Tong University

Shanghai Dongchuan Rd 800

Shanghai 200240

China

Phone: + 86 21 34 20 59 89

Fax: + 86 21 34 20 59 89

Email: kimhz@sjtu.edu.cn

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