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DOI: 10.1055/s-0029-1213531
© Karl F. Haug Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
Biochemische und immunologische Parameter der Alterung
Ansatz zu Prävention und TherapiePublication History
Publication Date:
10 June 2009 (online)
![](https://www.thieme-connect.de/media/ehk/200903/lookinside/thumbnails/10.1055-s-0029-1213531-1.jpg)
Zusammenfassung
Wachstumshormon und IGF-1 regulieren die Hirnfunktion. Mit der Alterung des Gehirns nimmt IGF-1 ab. Durch IGF-1-Zufuhr bei Mangel an Wachstumshormon und IGF-1 konnte tierexperimentell die Glukoseutilisation im Gehirn gebessert werden. IGF-1 und die IGF-1-Rezeptor-Genexpression wird durch Zinksupplementierung gesteigert.
IL-2 ist das wichtigste die Zellproliferation fördernde Zytokin. Mit der Alterung nimmt die IL-2-Sekretion ab, besonders bei Dementen. Durch Zinkzufuhr kann die IL-2-Abnahme wieder normalisiert werden.
Oxidativer Stress hat pathogenetische Bedeutung. Zur Entgiftung von Radikalen sind enzymatische Mechanismen notwendig. Dabei wirkt Zink antiinflammatorisch und membranstabilisierend.
Abstract
Growth hormone and IGF-1 regulate the brain function. With the ageing of the brain, IGF-1 decreases. In animal experiments it was possible to improve the utilization of glucose in the brain by supplying IGF-1 when a deficiency of growth hormone and IGF-1 was present. IGF-1 and the IGF-1 receptor gene expression are increased by zinc supplementation.
IL-2 is the most important cytokine which improves the cell proliferation. With ageing, the secretion of IL-2 is reduced, especially with people suffering from dementia. By supplying zinc, the reduction of IL-2 can be normalized again.
Oxidative stress is of pathogenic significance. Enzymatic mechanisms are necessary for the detoxification of radicals. In this case, zinc has an anti-inflammatory and membrane stabilizing effect.
Schlüsselwörter
Alterung - Wachstumshormon - IGF-1 - IL-2 - oxidativer Stress - Alzheimer-Krankheit - kognitive Störung - Antioxidanzien - Zinkmangel
Keywords
Ageing - growth hormone - IGF-1 - IL-2 - oxidative stress - Alzheimer’s disease - cognitive disorder - antioxidants - zinc deficiency
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