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DOI: 10.1055/s-0029-1215225
© Georg Thieme Verlag KG Stuttgart · New York
Extramedullary plasmacytoma of the colon: a rare cause of gastrointestinal bleeding
D. Collado Pacheco
Hospital Universitario Severo Ochoa
Avda Orellana s/n – 28911
Leganés
(Madrid)
Spain
Email: davidcolladopacheco@yahoo.es
Publication History
Publication Date:
17 November 2009 (online)
A 74-year-old man presented with a 48-hour history of diarrhea, abdominal pain, and rectal bleeding. He was known to have multiple myeloma, which had been diagnosed in 2001. Although complete remission was achieved after chemotherapy, the patient had two relapses: a malignant pericardial effusion (2003) and bone marrow relapse (May, 2008). Initial evaluation revealed an abdominal mass on the right side, hematochezia, hemoglobin level of 11.4 g/dL, and abnormal renal function. Urgent colonoscopy disclosed pseudomembranous colitis in the left colon, and the hepatic flexure was stiff. A large number of coalescent intracolonic masses were found, covered in some places by ulcerated mucosa with fibrin ([Fig. 1]).
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Fig. 1 a The hepatic flexure on colonoscopy. b Extramedullary plasmacytoma of the colon. c Ulcerated mucosa.
Right colon stenosis was also seen. Pathological examination showed an atypical plasmacytic cell infiltration of the mucosa ([Fig. 2]).
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Fig. 2 Histological section showing plasma cells.
Immunohistochemically, these cells showed reactivity for CD138, a marker of viable myeloma cells ([Fig. 3]).
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Fig. 3 Immunohistochemical staining positive for CD138.
Multiple myeloma is a neoplastic proliferation of monoclonal plasma cells, which can result in bone lesions, infections, kidney failure, bone marrow failure, hypercalcemia, and hyperviscosity syndrome. It is usually confined to the bone marrow. Extramedullary plasmacytomas comprise 4 % of all plasma cells tumors and occur mainly in the upper respiratory tract (82.2 %); the gastrointestinal tract is involved in only 7.2 % of cases [1]. All segments of the gastrointestinal tract may be involved, but the small bowel is the most common site of infiltration, followed by the stomach, colon, and esophagus. Clinical manifestations are usually nonspecific: anorexia, weight loss, abdominal pain, vomiting, gastrointestinal bleeding, intestinal obstruction, or malabsorption. There have been only a few published reports of the endoscopic features of gastrointestinal plasmacytoma, which usually manifests as ulcers, ulcerated masses, irregular thickened mucosa, or multiple polyps [2]. In this report we have presented the endoscopic appearance of this highly unusual tumor. To our knowledge, only 14 cases have been reported so far [3] [4] [5].
Endoscopy_UCTN_Code_CCL_1AD_2AC
#References
- 1 Alexiou C, Kau R J, Dietzfelbinger H. et al . Extramedullary plasmacytoma. Tumor occurrence and therapeutics concepts. Cancer. 1999; 85 240-242
- 2 Chim C S, Wong W M, Nicholls J. et al . Extramedullary sites of involvement in hematologic malignancies. Case 3: Hemorragic gastric plasmacytoma as the primary presentation in multiple myeloma. J Clin Oncol. 2002; 20 344-347
- 3 Gupta V, Nahak B, Sakhuja P. et al . Primary isolated plasmacytoma of the colon. World J Surg Oncol. 2007; 5 47
- 4 Doki T, Takeuchi O, Kaiho T. et al . Primary isolated extramedullary plasmacytoma of the colon. Int J Colorectal Dis. 2008; 23 719-720
- 5 Jones J E, Brand M I, Saclarides T J. et al . Primary extramedullary plasmacytomas of the colon. Am Surg. 2008; 74 873-874
D. Collado Pacheco
Hospital Universitario Severo Ochoa
Avda Orellana s/n – 28911
Leganés
(Madrid)
Spain
Email: davidcolladopacheco@yahoo.es
References
- 1 Alexiou C, Kau R J, Dietzfelbinger H. et al . Extramedullary plasmacytoma. Tumor occurrence and therapeutics concepts. Cancer. 1999; 85 240-242
- 2 Chim C S, Wong W M, Nicholls J. et al . Extramedullary sites of involvement in hematologic malignancies. Case 3: Hemorragic gastric plasmacytoma as the primary presentation in multiple myeloma. J Clin Oncol. 2002; 20 344-347
- 3 Gupta V, Nahak B, Sakhuja P. et al . Primary isolated plasmacytoma of the colon. World J Surg Oncol. 2007; 5 47
- 4 Doki T, Takeuchi O, Kaiho T. et al . Primary isolated extramedullary plasmacytoma of the colon. Int J Colorectal Dis. 2008; 23 719-720
- 5 Jones J E, Brand M I, Saclarides T J. et al . Primary extramedullary plasmacytomas of the colon. Am Surg. 2008; 74 873-874
D. Collado Pacheco
Hospital Universitario Severo Ochoa
Avda Orellana s/n – 28911
Leganés
(Madrid)
Spain
Email: davidcolladopacheco@yahoo.es
![](https://www.thieme-connect.de/media/endoscopy/2009S02/thumbnails/683cl1a.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
![](https://www.thieme-connect.de/media/endoscopy/2009S02/thumbnails/683cl1b.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
![](https://www.thieme-connect.de/media/endoscopy/2009S02/thumbnails/683cl1c.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
Fig. 1 a The hepatic flexure on colonoscopy. b Extramedullary plasmacytoma of the colon. c Ulcerated mucosa.
![](https://www.thieme-connect.de/media/endoscopy/2009S02/thumbnails/683cl2.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
Fig. 2 Histological section showing plasma cells.
![](https://www.thieme-connect.de/media/endoscopy/2009S02/thumbnails/683cl3.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
Fig. 3 Immunohistochemical staining positive for CD138.