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Synthesis 2009(14): 2361-2364
DOI: 10.1055/s-0029-1216844
DOI: 10.1055/s-0029-1216844
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient Fluoride-Mediated Synthesis of 5-Amino-Substituted Isothiazoles
Further Information
Received
13 March 2009
Publication Date:
25 May 2009 (online)
Publication History
Publication Date:
25 May 2009 (online)
Abstract
Fluoride-mediated nucleophilic substitution reactions of tert-butyl 4,5-dichloroisothiazole-3-carboxylate with various amines occur under mild conditions yielding 5-(alkylamino)isothiazoles in moderate to high yields.
Key words
isothiazole - fluoride - substitution - amine
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