A Practical Method for O-Acylation of N-Hydroxythiazole-2(3H)-thiones

Abstract

O-Acylation of 4- and 4,5-substituted N-hydroxythiazole-2(3H)-thiones occurred in solutions of acetone upon treatment with solid K₂CO₃ and a variety of neat acyl chlorides (primary, secondary, and tertiary alkyl, aryl; 60-87% yield; ∼10 g scale).

Key words

anhydride - acyl chloride - carbon radical - thiazolethione - thiohydroxamic acid

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