Synthesis of the Naturally Occurring (-)-1,3,5-Tri-O-Caffeoylquinic Acid

Abstract

Ribonuclease H (RNase H) is an essential component to the replication of human immunodeficiency virus (HIV), and only a few inhibitors of this enzyme are known. Millenia Hope Pharmaceuticals Inc. found that (-)-1,3,5-tri-O-caffeoylquinic acid is a potent RNase H inhibitor and antiviral agent. A facile route leading to this inhibitor from commercially available (-)-quinic acid is reported within.

Key words

reverse transcriptase - ribonuclease H - (-)-1,3,5-tri-O-caffeoylquinic acid - (-)-quinic acid

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