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Synthesis 2009(15): 2531-2534
DOI: 10.1055/s-0029-1217397
DOI: 10.1055/s-0029-1217397
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Gas-Phase Synthesis of N-Unsubstituted 3-Hydroxypyrroles and 1H-Pyrrol-3(2H)-ones
Further Information
Received
8 April 2009
Publication Date:
23 June 2009 (online)
Publication History
Publication Date:
23 June 2009 (online)

Abstract
Flash vacuum pyrolysis (FVP) at 600 ˚C of methylaminomethylene derivatives of Meldrum’s acid bearing electron-withdrawing substituents on the methyl group, provides N-unsubstituted 3-hydroxypyrroles and/or 1H-pyrrol-3(2H)-ones in high yield.
Key words
gas-phase reactions - pericyclic reactions - heterocycles - pyrroles - regioselectivity
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