Glycosylations of Tertiary Alcohols:
Synthesis of Fully Protected Disaccharides with Sterically
Demanding Groups Attached to the Sugar Core

Annika Holkenbrink; Jordi Bertrán Vicente; Daniel B. Werz

doi:10.1055/s-0029-1217403

PAPER

Glycosylations of Tertiary Alcohols: Synthesis of Fully Protected Disaccharides with Sterically Demanding Groups Attached to the Sugar Core

Annika Holkenbrink, Jordi Bertrán Vicente, Daniel B. Werz*
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen, Germany
Fax: +49(551)399476; e-Mail: dwerz@gwdg.de;

Abstract

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Abstract

Modified gluco- and galactopyranosides with sterically demanding groups in the 4-position were synthesized. Glycosylation studies of these tertiary alcohols with glycosyl trichloroacetimidates and glycosyl phosphates were performed. Despite steric hindrance the modified disaccharide moieties could be assembled in moderate yields.

Key words

carbohydrates - glycosylation - steric hindrance - glycosides

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Referenzen

References

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