Easy Silica Gel Supported Desymmetrization of PEG

Abstract

Our work shows how poly(ethylene glycol), differentially functionalized at two ends, can be easily and efficiently synthesized from commercial symmetric dihydroxy PEG 600. First, we linked the polymer onto functionalized silica gel using one of its ­hydroxy ends. Then, the second hydroxy group was modified, and finally, the desymmetrized PEG was cleaved from the solid support.

Key words

desymmetrization - mono protection - poly(ethylene glycol) polymer - solid phase

References and Notes

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32

The loading was calculated by treating 1 g of pegylated silica gel 3 with cleavage solution and weighting the recovered PEG.

34

Analytical sample was treated with NaBH₄ and analyzed with mass spectrometer. ESI-MS (most intense peaks): (n = 10) 541.4 [M + Na⁺]; (n = 11) 585.4 [M + Na⁺]; (n = 12) 629.9 [M + Na⁺].