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Synlett 2009(20): 3307-3310  
DOI: 10.1055/s-0029-1218369
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Pentafluorophenyl Esters of Nitroveratryloxycarbonyl-Protected Amino Acids

Dong-Sik Shin, Yoon-Sik Lee*
School of Chemical & Biological Engineering, Seoul National University, Kwanak-Ku, Seoul 151-744, Korea
Fax: +82(2)8769625; e-Mail: yslee@snu.ac.kr;
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Publication History

Received 16 September 2009
Publication Date:
18 November 2009 (online)

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Abstract

For efficient peptide synthesis on a glass chip, 20 kinds of pentafluorophenyl (Pfp) esters of nitroveratryloxycarbonyl (NVOC)-protected amino acids were synthesized by using Pfp tri­fluoroacetate. Simple purification step gave moderate to high yield. The first loading time of each amino acid on glass surface was 30-60 min. The UV cleavage of the NVOC group was completed within 10 minutes.

Key words

NVOC amino acid - Pfp ester - in situ synthesis - peptide microarray