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Synthesis 2010(5): 797-802
DOI: 10.1055/s-0029-1218621
DOI: 10.1055/s-0029-1218621
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Stereoseletive Total Synthesis of 11-α- and 11-β-Methoxycurvularins
Further Information
Received
19 October 2009
Publication Date:
08 January 2010 (online)
Publication History
Publication Date:
08 January 2010 (online)
Abstract
Total synthesis of 11-α-methoxycurvularin and 11-β-methoxycurvularin has been accomplished in a highly stereoselective manner by utilizing Jacobsen hydrolytic kinetic resolution, Maruoka asymmetric allylation and intramolecular Friedel-Crafts acylation as key steps.
Key words
11-α-methoxycurvularin - 11-β-methoxycurvularin - Jacobsen resolution - Maruoka asymmetric allylation - intramolecular Friedel-Crafts acylation
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