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Synthesis 2010(6): 985-990
DOI: 10.1055/s-0029-1218630
DOI: 10.1055/s-0029-1218630
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Novel Synthesis of Heterocycle-Annulated Azocine Derivatives of Biological Relevance by Aromatic Aza-Claisen Rearrangement and Intramolecular Heck Reaction
Further Information
Received
19 November 2009
Publication Date:
04 January 2010 (online)
Publication History
Publication Date:
04 January 2010 (online)
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Abstract
A synthetic strategy based on the sequential application of an aromatic aza-Claisen rearrangement and an intramolecular Heck reaction sequence as the key steps has been developed for the synthesis of various hitherto unreported coumarin- and quinolone-annulated benzazocine derivatives in excellent yields.
Key words
aza-Claisen rearrangement - Heck reaction - benzazocine - coumarin - quinolone - palladium catalyst
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