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Synthesis 2010(6): 908-910
DOI: 10.1055/s-0029-1218643
DOI: 10.1055/s-0029-1218643
SHORTPAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient Copper-Catalyzed N-Arylation of Amides and Imidazoles with Aryl Iodides
Further Information
Publication History
Received
22 October 2009
Publication Date:
08 January 2010 (online)
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Abstract
The C-N cross-coupling of amides and imidazoles with aryl iodides is described using CuI in tetrabutylammonium bromide (TBAB) under ligand-free conditions. The reaction is simple, general, and efficient affording the C-N cross-coupled products in shorter time and in high yield.
Key words
N-arylation - amides - imidazoles - copper iodide - TBAB
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