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Exp Clin Endocrinol Diabetes 2010; 118(5): 298-303
DOI: 10.1055/s-0029-1224153
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

In Vitro Effect of Octyl – Methoxycinnamate (OMC) on the Release of Gn-RH and Amino Acid Neurotransmitters by Hypothalamus of Adult Rats

S. Carbone2 , B. Szwarcfarb2 , R. Reynoso1 , O. J. Ponzo1 , N. Cardoso1 , E. Ale1 , J. A. Moguilevsky3 , P. Scacchi1
  • 1Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina
  • 2Departamento de Fisiología, CONICET, Buenos Aires, Argentina
  • 3Departamento de Fisiología, y Facultad de Posgrado, Universidad Favaloro, Buenos Aires, Argentina
Further Information

Publication History

received 22.10.2008 first decision 22.04.2008

accepted 12.05.2009

Publication Date:
02 March 2010 (online)

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Abstract

OMC (octyl-methoxycinnamate), an endocrine disruptor having estrogenic activity, is used in sunscreen creams as UV filter. We studied its “in vitro” effects on the hypothalamic release of Gn-RH as well as on the amino acid neurotransmitter system. OMC significantly decreased Gn-RH release in normal male and female rats as well as in castrated rats with substitutive therapy. No effects were observed in castrated rats without substitutive therapy. In males OMC increases the release of GABA, decreasing the production of glutamate (GLU) while in the female decreases the excitatory amino acid aspartate (ASP) and GLU without modifications in the hypothalamic GABA release. These results suggest that OMC acting as endocrine disruptor could alter the sex hormone-neurotransmitter-Gn-RH axis relationships in adult rats.

Key words

UV filters - hypothalamic Gn-RH - amino acid neurotransmitters - OMC

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1 This work was supported by Grants from Agencia de Promoción Científica y Técnica BID 1728 PIC 2003 and the University of Buenos Aires.

Correspondence

Dr. P. Scacchi

Departamento de Fisiología

Facultad de Medicina

Universidad de Buenos Aires

Paraguay 2155,(1121)

Buenos Aires

Argentina

Phone: 054-011-5950-9500 (2147)

Email: pscacchi@fmed.uba.ar