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pferde spiegel 2009; 12(4): 155-163
DOI: 10.1055/s-0029-1240592
fachspiegel

© Enke Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Septische Arthritis beim adulten Pferd – Eine Übersicht etablierter und neuer Behandlungsansätze

Septic arthritis in the adult horse – Overview of established and new strategies of therapyBianca Carstanjen, Sara Boehart, Stefan Rattenhuber
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Publication History

Publication Date:
14 December 2009 (online)

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Zusammenfassung

Die septische Arthritis ist eine schwerwiegende Erkrankung, die sich ohne rigorose Behandlungsmaßnahmen zu einer lebensbedrohlichen Situation entwickeln kann. Andererseits ist durch eine schnelle Anwendung sowohl etablierter als auch neuer Therapiemethoden die vollständige Wiederherstellung der infizierten Strukturen möglich, bevor sie irreversibel geschädigt werden. Dieser Artikel soll eine Zusammenfassung der Literatur zur systematischen Aufarbeitung von Ätiologie, Diagnose und Behandlungsstrategien septischer Prozesse im Gelenk beim ausgewachsenen Pferd leisten.

Summary

Infection of synovial structures in adult horses is a serious disease and can become life-threatening. The affected horse might completely recover in case the infection can be eliminated before an irreversible damage of the affected structure occurs. This article gives an overview concerning etiology, diagnosis and strategies for therapy concerning infections of articular structures in horses.

Schlüsselwörter

Pferd - Infektion - Arthritis - Antibiotika - Behandlung

Key words

horse - infection - arthritis - antibiotics - therapy

Literatur

  • 1 Adams S B. Techniques for local antimicrobial delivery for treatment of orthopedic infections.  NAVC Proceedings. 2006;  63-65
    Google Scholar
  • 2 American Association of Equine Practitioners .Guide for veterinary service and judging of equestrian events: definition and classification of lameness. Lexington, USA; AAEP 1991: 19
    Google Scholar
  • 3 Baxter G M. Management of wounds involving synovial structures in horses.  Clin tech Equine Pract. 2004;  3 204-214
    CrossrefGoogle Scholar
  • 4 Bertone A L. Infectious arthritis. McIlwraith CW, Trotter G Joint disease in the horse. 1st edition. Philadelphia; WB Saunders 1996: 397-409
    Google Scholar
  • 5 Bertone A L, McIlwraith C W, Jones R L. Comparison of various treatments for experimentally induced equine infectious arthritis.  Am J Vet Res. 1987a;  48 519-529
    Google Scholar
  • 6 Bertone A L, McIlwraith C W, Jones R L, Norrdin R W, Radin M J. Povidone-iodine lavage treatment of experimentally induced equine infectious arthritis.  Am J Vet Res. 1987b;  48 712-715
    Google Scholar
  • 7 Bertone A, Caprile K, Davis D. Serum and synovial concentrations of gentamicin administered chronically to horses with experimentally-induced septic arthritis.  Vet Surg. 1990;  19 57
    Google Scholar
  • 8 Bertone A L, Tremaine W H, Macoris D G, Simmons E J, Ewert K M, Herr L G, Weisbrode S E. Effect of long-term administration of an injectable enrofloxacin solution on physical and musculoskeletal variables in adult horses.  J Am Vet Med Assoc. 2000;  217 1514-1521
    CrossrefGoogle Scholar
  • 9 Brown M P, Mayo M B, Gronwall R R. Serum and synovial fluid concentrations of ampicillin trihydrate in calves with suppurative arthritis.  Cornell Vet. 1991;  81 137-143
    Google Scholar
  • 10 Buchholz H W, Elson R A, Heinert K. Antibiotic-loaded acrylic cement: current concepts.  Clin Orthop Relat Res. 1984;  190 96-108
    Google Scholar
  • 11 Buggot J D, Prescott J F. Antimicrobial selection and dosage in the treatment of equine bacterial infections.  Equine Vet J. 1987;  19 92-96
    CrossrefGoogle Scholar
  • 12 Butt T D, Bailey J V, Dowling P M, Fretz P B. Comparison of 2 techniques for regional antibiotic delivery to the equine forelimb: intraosseous perfusion vs. intravenous perfusion.  Can Vet J. 2001;  42 617-622
    Google Scholar
  • 13 Caron J P, Genovese R L. Principles and practices of joint disease treatment. Ross MW, Dyson SJ Diagnosis and management of lameness in horses. St. Louis; WB Saunders 2003: 746-764
    Google Scholar
  • 14 Dowling P M. Antimicrobial therapy. Bertone J Equine clinical pharmacology. St. Louis; Saunders 2004: 40-43
    Google Scholar
  • 15 Ducharme N G, Mitchell L. Advances in the treatment of bone and joint infections in foals. Prag; Proc ECVS 2004: 181-183
    Google Scholar
  • 16 Dyson S J, Murray R, Schramme M, Branch M. Magnetic resonance imaging of the equine foot: 15 horses.  Equine Vet J. 2003;  35 18-26
    CrossrefGoogle Scholar
  • 17 Errecalde J O, Carmely D, Mariño E L, Mestorino N. Pharmacokinetics of amoxycillin in normal horses and horses with experimental arthritis.  J Vet Pharmacol Ther. 2001;  24 1-6
    CrossrefGoogle Scholar
  • 18 Farnsworth K D, White N A, Robertson J. The effect of implanting gentamicin-impregnated polymethylmethacrylate beads in the tarsocrural joint of the horse.  Vet Surg. 2001;  30 126-131
    CrossrefGoogle Scholar
  • 19 Finsterbush A, Argaman M, Sacks T. Bone and joint perfusion with antibiotics in the treatment of experimental staphylococcal infection in rabbits.  J Bone Joint Surg Am. 1970;  52 1424-1432
    Google Scholar
  • 20 Finsterbush A, Weinberg H. Venous perfusion of the limb with antibiotics for osteomyelitis and other chronic infections.  J Bone Joint Surg Am. 1972;  54 1227-1234
    Google Scholar
  • 21 Firth E C, Klein W R, Nouws J F, Wensing T. Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies.  J Vet Pharmacol Ther. 1988;  11 56-62
    CrossrefGoogle Scholar
  • 22 Gibbon K T, McIlwraith C W, Turner A S, Stashak T S, Aanes W A, Trotter G W. Open joint injuries in horses: 58 cases (1980–1986).  J Am Vet Med Assoc. 1989;  194 398-404
    Google Scholar
  • 23 Gough M, Munroe G, Mayhew I. Urea as a measure of dilution of equine synovial fluid.  Equine Vet J. 2002;  34 76-79
    CrossrefGoogle Scholar
  • 24 Hartmann F A, Trostle S S, Klohnen A A. Isolation of methicillin-resistant Staphylococcus aureus from a postoperative wound infection in a horse.  J Am Vet Med Assoc. 1997;  211 590-592
    Google Scholar
  • 25 Hirsh D C, Ruehl W W. A rational approach to the selection of an antimicrobial agent.  J Am Vet Med Assoc. 1984;  185 1058-1061
    Google Scholar
  • 26 Jenning P B. Surgical techniques utilized in the presence of infection.  Vet Surg. 2008;  4 43-46
    Google Scholar
  • 27 Lloyd K C K, Stover S M, Pascoe J R, Buggot J D, Kurperstoek C, Heitala S. Plasma and synovial fluid concentration of gentamicin in horses after intra-articular administration of buffered and unbuffered gentamicin.  Am J Vet Res. 1988;  49 644-649
    Google Scholar
  • 28 Lugo J, Gaughan E M. Septic arthritis, tenosynovitis, and infections of hoof structures.  Vet Clin North Am Equine Pract. 2006;  22 363-388
    CrossrefGoogle Scholar
  • 29 Mattson S E, Pearce S G, Bouré L P, Dobson H, Hurtig M B, Black W D. Comparison of intraosseous and intravenous infusion of technetium Tc 99 m pertechnate in the distal portion of forelimbs in standing horses by use of scintigraphic imaging.  Am J Vet Res. 2005;  66 1267-1272
    CrossrefGoogle Scholar
  • 30 Meagher D T, Latimer F G, Sutter W W, Saville W J. Evaluation of a balloon constant rate infusion system for treatment of septic arthritis, septic tenosynovitis, and contaminated synovial wounds: 23 cases (2002–2005).  J Am Vet Med Assoc. 2006;  228 1930-1934
    CrossrefGoogle Scholar
  • 31 Meijer M C, van Weeren P R, Rijkenhuizen A B. Clinical experiences of treating septic arthritis in the equine by repeated joint lavage: a series of 39 cases.  Vet Med A Physiol Pathol Clin Med. 2000;  47 351-365
    Google Scholar
  • 32 Morton A J. Diagnosis and treatment of septic arthritis.  Vet Clin North Am Equine Pract. 2005;  21 627-649
    CrossrefGoogle Scholar
  • 33 Orsini J A, Moate P J, Engiles J, Norman T, Poppenga R, Benson C E, Boston R C. Cefotaxime kinetics in plasma and synovial fluid following intravenous administration in horses.  J Vet Pharmacol Ther. 2004;  27 293-298
    CrossrefGoogle Scholar
  • 34 Palmer S E, Hogan P M. How to perform regional limb perfusion in the standing horse.  Proc Am Assoc Equine Pract. 1999;  45 124-127
    Google Scholar
  • 35 Ramos J R, Howard R D, Pleasant R S, Moll H D, Blodgett D J, Magnin G, Inzana T J. Elution of metronidazole and gentamicin from polymethylmethacrylate beads.  Vet Surg. 2003;  32 251-261
    CrossrefGoogle Scholar
  • 36 Ross M W, Orsini J A, Richardson D W, Martin B B. Closed suction drainage in the treatment of infectious arthritis of the equine tarsocrural joint.  Vet Surg. 1991;  20 21-29
    CrossrefGoogle Scholar
  • 37 Sayegh A I, Moore R M. Polymethylmetacrylate beads for treating orthopaedic infections.  Comp Contin Educ Pract Vet. 2003;  25 788-794
    Google Scholar
  • 38 Scheuch B C, van Hoogmoed L M, Wilson W D, Snyder J R, MacDonald M H, Watson Z E, Steffey E P. Comparison of intraosseous or intravenous infusion for delivery of amikacin sulfate to the tibiotarsal joint of horses.  Am J Vet Res. 2002;  63 374-380
    CrossrefGoogle Scholar
  • 39 Schneider R K, Bramlage L R, Moore R M, Mecklenburg L M, Kohn C W, Gabel A A. A retrospective study of 192 horses affected with septic arthritis/tenosynovitis.  Equine Vet J. 1992a;  24 436-442
    CrossrefGoogle Scholar
  • 40 Schneider R K, Bramlage L R, Mecklenburg L M, Moore R M, Gabel A A. Open drainage, intra-articular and systemic antibiotics in the treatment of septic arthritis/tenosynovitis in horses.  Equine Vet J. 1992b;  24 443-449
    CrossrefGoogle Scholar
  • 41 Schneider R K. Common bacteria encountered in septic arthritis.  Proc AAEP. 1998a;  44 152-158
    Google Scholar
  • 42 Schneider R K. Treatment of posttraumatic septic arthritis.  Proc AAEP. 1998b;  44 167-171
    Google Scholar
  • 43 Smith R, Kajyama G, Scherman D J. Staphylococcal infectious arthritis: Antibiotic and nonsteroidal anti-inflammatory treatment in a rabbit model.  J Orthop Res. 1997;  15 919-926
    CrossrefGoogle Scholar
  • 44 Sonmezoglu K, Sonmezoglu M, Halac M, Akgün I, Turkmen C, Onsel C, Kanmaz B, Solanki K, Britton K E, Uslu I. Usefulness of 99 mTc-ciprofloxacin (infecton) scan in diagnosis of chronic orthopedic infections: comparative study with 99 mTc-HMPAO leukocyte scintigraphy.  J Nucl Med. 2001;  42 567-574
    Google Scholar
  • 45 Steel C M. Equine synovial fluid analysis.  Vet Clin North Am Equine Pract. 2008;  24 437-454
    CrossrefGoogle Scholar
  • 46 Summerhays G E. Treatment of traumatically induced synovial sepsis in horses with gentamicin-impregnated collagen sponges.  Vet Rec. 2000;  147 184-188
    CrossrefGoogle Scholar
  • 47 Todhunter R J, Fubini S L, Vernier-Singer M, Wootton J A, Lust G, Freeman K P, MacLeod J N. Acute synovitis and intra-articular methylprednisolone acetate in ponies.  Osteoarthritis Cartilage. 1998;  6 94-105
    CrossrefGoogle Scholar
  • 48 Tulamo R M, Bramlage L R, Gabel A A. The influence of corticosteroids on sequential clinical and synovial fluid parameters in joints with acute infectious arthritis in the horse.  Equine Vet J. 1989;  21 332-337
    CrossrefGoogle Scholar
  • 49 Werner L A, Hardy J, Bertone A L. Bone gentamicin concentration after intra-articular injection or regional intravenous perfusion in the horse.  Vet Surg. 2003;  32 559-565
    CrossrefGoogle Scholar
  • 50 Wilson D G, Cooley A J, MacWilliams P S, Markel M D. Effects of 0.05 % chlorhexidine lavage on the tarsocrural joints of horses.  Vet Surg. 1994;  23 442-447
    CrossrefGoogle Scholar
  • 51 Wright I M, Smith M R, Humphrey D J, Eaton-Evans T C, Hillyer M H. Endoscopic surgery in the treatment of contaminated and infected synovial cavities.  Equine Vet J. 2003;  35 613-619
    CrossrefGoogle Scholar

PD Dr., PhD Bianca Carstanjen

Zugspitzstraße 11

82362 Weilheim

Email: carst@zedat.fu-berlin.de

Dr. Stefan Rattenhuber

Tierklinik Seehof
Pferde Physiotherapie Centrum

Seehof 2a

86911 Dießen

Email: info@tierklinikseehof.de